prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer

Stable Identifier
Reaction [binding]
Homo sapiens
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Prekallikrein (PK) associates specifically with kininogen (HK) on cell surfaces. In vivo, this reaction may occur primarily on the surfaces of endothelial cells in response to platelet activation (Lin et al. 1997; Motta et al. 1998; Mahdi et al. 2003).

Literature References
PubMed ID Title Journal Year
9226169 High molecular weight kininogen peptides inhibit the formation of kallikrein on endothelial cell surfaces and subsequent urokinase-dependent plasmin formation

Yan, W, Zhang, H, McCrae, KR, Colman, RW, Harris, RB, Lin, Y

Blood 1997
3521732 Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats

Fujikawa, K, McMullen, BA, Chung, DW, Davie, EW

Biochemistry 1986
12944405 The relative priority of prekallikrein and factors XI/XIa assembly on cultured endothelial cells

Schmaier, AH, Shariat-Madar, Z, Mahdi, F

J Biol Chem 2003
9427705 High molecular weight kininogen regulates prekallikrein assembly and activation on endothelial cells: a novel mechanism for contact activation

Schmaier, AH, Cines, DB, Rojkjaer, R, Hasan, AA, Motta, G

Blood 1998
Orthologous Events
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