Reactome | prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer

prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer

Stable Identifier

R-HSA-158218

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

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prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer

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Prekallikrein (PK) associates specifically with kininogen (HK) on cell surfaces. In vivo, this reaction may occur primarily on the surfaces of endothelial cells in response to platelet activation (Lin et al. 1997; Motta et al. 1998; Mahdi et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
3521732	Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats Chung, DW, Fujikawa, K, McMullen, BA, Davie, EW	Biochemistry	1986
9226169	High molecular weight kininogen peptides inhibit the formation of kallikrein on endothelial cell surfaces and subsequent urokinase-dependent plasmin formation Lin, Y, Harris, RB, Yan, W, McCrae, KR, Zhang, H, Colman, RW	Blood	1997
12944405	The relative priority of prekallikrein and factors XI/XIa assembly on cultured endothelial cells Mahdi, F, Shariat-Madar, Z, Schmaier, AH	J Biol Chem	2003
9427705	High molecular weight kininogen regulates prekallikrein assembly and activation on endothelial cells: a novel mechanism for contact activation Motta, G, Rojkjaer, R, Hasan, AA, Cines, DB, Schmaier, AH	Blood	1998