factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex

Stable Identifier
Reaction [binding]
Homo sapiens
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Plasma factor XI binds to the platelet glycoprotein Ib:IX:V complex (Baglia et al. 2004; Greengard et al. 1986). In the body, this reaction occurs specifically on the surfaces of activated platelets, but not on endothelial cells (Baird and Walsh 2002). The stoichiometry of the platelet glycoprotein Ib:IX:V complex has not been established directly, but is inferred from the relative abundances of its components in platelet membranes (Modderman et al. 1992; Shrimpton et al. 2002).
Literature References
PubMed ID Title Journal Year
33471623 Role of platelets in regulating activated coagulation factor XI activity

McCarty, OJT, Tucker, EI, Pang, J, Puy, C, Lorentz, CU, Reitsma, SE, Shatzel, JJ, Gailani, D, Raghunathan, V, Gruber, A

Am J Physiol Cell Physiol 2021
12391017 Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation

Lopez, JA, Borthakur, G, Shrimpton, CN, Cruz, MA, Dong, JF, Larrucea, S

J Exp Med 2002
3017409 Binding of coagulation factor XI to washed human platelets

Heeb, MJ, Griffin, JH, Ersdal, E, Greengard, JS, Walsh, PN

Biochemistry 1986
1730602 Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane

Admiraal, LG, von dem Borne, AE, Modderman, PW, Sonnenberg, A

J Biol Chem 1992
15317813 Identification of a binding site for glycoprotein Ibalpha in the Apple 3 domain of factor XI

Lopez, JA, Walsh, PN, Gailani, D, Baglia, FA

J Biol Chem 2004
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