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factor VIIIa A1 polypeptide [plasma membrane]
Stable Identifier
R-HSA-158121
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
F8(20-391)
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of hemostasis (Homo sapiens)
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) (Homo sapiens)
Defective factor IX causes hemophilia B (Homo sapiens)
Defective F9 variant does not activate FX (Homo sapiens)
FIXa variant:FVIIIa does not convert FX to the active FXa (Homo sapiens)
factor VIIIa:factor IXa variant [plasma membrane] (Homo sapiens)
factor VIIIa [plasma membrane] (Homo sapiens)
factor VIIIa A1 polypeptide [plasma membrane] (Homo sapiens)
Defective factor IX causes thrombophilia (Homo sapiens)
Hyperactivation of factor X by FVIIIa:FIXa R384L (Homo sapiens)
FVIIIa:FIXa R384L [plasma membrane] (Homo sapiens)
factor VIIIa [plasma membrane] (Homo sapiens)
factor VIIIa A1 polypeptide [plasma membrane] (Homo sapiens)
Defective factor VIII causes hemophilia A (Homo sapiens)
Defective cofactor function of FVIIIa variant (Homo sapiens)
FVIIIa variant:FIXa does not convert FX to the active FXa (Homo sapiens)
FVIIIa variant:FIXa [plasma membrane] (Homo sapiens)
factor VIIIa variant [plasma membrane] (Homo sapiens)
factor VIIIa A1 polypeptide [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Homo sapiens)
factor VIIIa [plasma membrane] (Homo sapiens)
factor VIIIa A1 polypeptide [plasma membrane] (Homo sapiens)
factor VIIIa:factor IXa [plasma membrane] (Homo sapiens)
factor VIIIa [plasma membrane] (Homo sapiens)
factor VIIIa A1 polypeptide [plasma membrane] (Homo sapiens)
factor VIIIa associates with cell membrane (Homo sapiens)
factor VIIIa [plasma membrane] (Homo sapiens)
factor VIIIa A1 polypeptide [plasma membrane] (Homo sapiens)
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Homo sapiens)
FVIIIa:FIXa:PROS1 [plasma membrane] (Homo sapiens)
factor VIIIa:factor IXa [plasma membrane] (Homo sapiens)
factor VIIIa [plasma membrane] (Homo sapiens)
factor VIIIa A1 polypeptide [plasma membrane] (Homo sapiens)
factor VIIIa:factor IXa [plasma membrane] (Homo sapiens)
factor VIIIa [plasma membrane] (Homo sapiens)
factor VIIIa A1 polypeptide [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00451 F8
Gene Names
F8, F8C
Chain
signal peptide:1-19, chain:20-2351, chain:20-1332, chain:20-759, chain:760-1332, chain:1668-2351
Reference Genes
BioGPS Gene:2157 F8
COSMIC (genes):F8 F8
CTD Gene:2157 F8
dbSNP Gene:2157 F8
ENSEMBL:ENSG00000185010 F8
HGNC:3546 F8
KEGG:hsa:2157 F8
Monarch:2157 F8
NCBI Gene:2157 F8
OMIM:300841 F8
UCSC:P00451 F8
Reference Transcript
RefSeq:NM_019863.2 F8
RefSeq:NM_000132.3 F8
Participates
as a component of
factor VIIIa variant [plasma membrane] (Homo sapiens)
factor VIIIa [plasma membrane] (Homo sapiens)
Other forms of this molecule
F8(392-759) D579A [plasma membrane]
F8(392-759) V578A [plasma membrane]
F8(392-759) R546W [plasma membrane]
F8(392-759) S577F [plasma membrane]
F8(392-759) I585T [plasma membrane]
F8 N637S [endoplasmic reticulum lumen]
F8 G2013R [endoplasmic reticulum lumen]
F8 W604R [endoplasmic reticulum lumen]
F8 R1126W [endoplasmic reticulum lumen]
F8 R2326L [endoplasmic reticulum lumen]
F8 P947R [endoplasmic reticulum lumen]
F8 H1066Y [endoplasmic reticulum lumen]
F8 S603G [endoplasmic reticulum lumen]
F8 E1057K [endoplasmic reticulum lumen]
F8 E600D [endoplasmic reticulum lumen]
F8 W604C [endoplasmic reticulum lumen]
F8 D845E [endoplasmic reticulum lumen]
F8 G720S [endoplasmic reticulum lumen]
F8 E600Q [endoplasmic reticulum lumen]
F8 R2326Q [endoplasmic reticulum lumen]
F8 R602G [endoplasmic reticulum lumen]
F8 A1610S [endoplasmic reticulum lumen]
F8 D599H [endoplasmic reticulum lumen]
F8 S603T [endoplasmic reticulum lumen]
F8 V2144_Y2351delinsHGVLENGKNWEPSYRW [endoplasmic reticulum lumen]
F8 R1329H [endoplasmic reticulum lumen]
F8 N601K [endoplasmic reticulum lumen]
F8 R2016W [endoplasmic reticulum lumen]
F8 L1481P [endoplasmic reticulum lumen]
F8 S603R [endoplasmic reticulum lumen]
F8 M633T [endoplasmic reticulum lumen]
F8 N1941S [endoplasmic reticulum lumen]
F8 A488T [endoplasmic reticulum lumen]
F8 R612C [endoplasmic reticulum lumen]
F8 D337N [endoplasmic reticulum lumen]
F8 A20_M2143delinsMRIQDPGK [endoplasmic reticulum lumen]
F8 D599V [endoplasmic reticulum lumen]
F8 N2137Q [endoplasmic reticulum lumen]
F8 E600K [endoplasmic reticulum lumen]
F8 N601D [endoplasmic reticulum lumen]
F8 N601H [endoplasmic reticulum lumen]
F8 C348S [endoplasmic reticulum lumen]
F8 S603C [endoplasmic reticulum lumen]
F8 A488S [endoplasmic reticulum lumen]
F8 N1941D [endoplasmic reticulum lumen]
F8 G1967D [endoplasmic reticulum lumen]
F8 P2067L [endoplasmic reticulum lumen]
F8 G720D [endoplasmic reticulum lumen]
F8 P2162L [endoplasmic reticulum lumen]
F8 M633I [endoplasmic reticulum lumen]
F8 C348R [endoplasmic reticulum lumen]
F8 R2178C [extracellular region]
F8 I2117S [extracellular region]
F8 P2319S [extracellular region]
F8 P2319L [extracellular region]
F8 P1828L [extracellular region]
F8 R2323H [extracellular region]
F8 S2138Y [extracellular region]
F8 R2169H [extracellular region]
F8 Y1699F [extracellular region]
F8 S2192I [extracellular region]
F8 Q2106E [extracellular region]
F8 R2326Q [extracellular region]
F8 Q2330P [extracellular region]
F8 A2220P [extracellular region]
F8 A2220del [extracellular region]
F8 R1708C [extracellular region]
F8 R1708H [extracellular region]
F8 R391C [extracellular region]
F8 R391H [extracellular region]
F8 S392L [extracellular region]
F8 Y365C [extracellular region]
factor VIIIa A2 polypeptide [plasma membrane]
factor VIIIa A3 C1 C2 polypeptide [plasma membrane]
factor VIII heavy chain [extracellular region]
factor VIII light chain [extracellular region]
factor VIIIa a3 acidic polypeptide [extracellular region]
F8(20-391) [extracellular region]
FVIII (392-759) [extracellular region]
F8(1709-2351) [extracellular region]
factor VIIIa B chain [extracellular region]
Factor VIII precursor [endoplasmic reticulum lumen]
Coagulation factor VIII precursor [platelet alpha granule lumen]
Factor VIII precursor [extracellular region]
Factor VIII precursor [COPII-coated ER to Golgi transport vesicle]
Factor VIII precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]
F8(20-391) A303E [extracellular region]
F8(20-391) S308L [extracellular region]
F8(392-759) R550C [extracellular region]
F8(392-759) R717W [extracellular region]
F8(392-759) R717L [extracellular region]
F8(392-759) R550H [extracellular region]
F8(392-759) R550G [extracellular region]
F8(392-759) N713I [extracellular region]
F8(356-372) [extracellular region]
F8(582-640) [extracellular region]
F8(20-355) [extracellular region]
F8(373-581) [extracellular region]
F8 Y1699F [Golgi lumen]
Factor VIII precursor [Golgi lumen]
OSulf-6Y-FVIII precursor [Golgi lumen]
Inferred To
F8 [plasma membrane]
(Bos taurus)
F8 [plasma membrane]
(Mus musculus)
F8 [plasma membrane]
(Rattus norvegicus)
factor VIIIa A1 polypeptide [plasma membrane]
(Gallus gallus)
Cross References
Guide to Pharmacology - Targets
2607
OpenTargets
ENSG00000185010
ENSEMBL
ENSP00000353393
,
ENSG00000185010
,
ENST00000330287
,
ENST00000360256
,
ENSP00000327895
ZINC - Substances
FA8_HUMAN
ZINC target
P00451
PRO
P00451
GlyGen
P00451
PDB
7KWO
,
6MF0
,
3HNY
,
4BDV
,
5K8D
,
1CFG
,
4KI5
,
1FAC
,
3HNB
,
6MF2
,
3HOB
,
8G6I
,
1IQD
,
1D7P
,
2R7E
,
3CDZ
,
7K66
,
3J2Q
,
3J2S
,
7KBT
,
8TY1
,
9D5D
,
4XZU
,
4PT6
GeneCards
F8
HPA
ENSG00000185010-F8
Pharos - Targets
P00451
Orphanet
F8
ZINC - Predictions - Purchasable
FA8_HUMAN
HMDB Protein
HMDBP01727
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04275 VWF
20
VWF(23-763) [extracellular region]
(R-HSA-67271)
VWF(764-2813) [extracellular region]
(R-HSA-158327)
VWF(23-763) [platelet alpha granule lumen]
(R-HSA-114662)
VWF L1733P (764-2813) [extracellular region]
(R-HSA-9824345)
VWF S1731L (764-2813) [extracellular region]
(R-HSA-9823681)
VWF K1794E (764-2813) [extracellular region]
(R-HSA-9823657)
VWF S1731T (764-2813) [extracellular region]
(R-HSA-9823615)
VWF S1783A (764-2813) [extracellular region]
(R-HSA-9823588)
VWF H1786D (764-2813) [extracellular region]
(R-HSA-9823634)
VWF W1745C (764-2813) [extracellular region]
(R-HSA-9823611)
VWF(764-1605) [extracellular region]
(R-HSA-9822545)
VWF (1606-2813) [extracellular region]
(R-HSA-9822534)
VWF G1579R (764-2813) [extracellular region]
(R-HSA-9844214)
VWF Y1584C (764-2813) [extracellular region]
(R-HSA-9844202)
VWF G1631D (764-2813) [extracellular region]
(R-HSA-9844230)
VWF C1099P (764-2813) [extracellular region]
(R-HSA-9844221)
VWF I1568N (764-2813) [extracellular region]
(R-HSA-9844203)
VWF Y1584C (764-1605) [extracellular region]
(R-HSA-9852765)
VWF G1631D (1606-2813) [extracellular region]
(R-HSA-9852788)
VWF I1568N (764-1605) [extracellular region]
(R-HSA-9852790)
0.623
2
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