Formation of translation initiation complexes containing mRNA that does not circularize

Stable Identifier
R-HSA-157849
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Formation of translation initiation complexes containing mRNA that does not circularize
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H. eIF4G in the eIF4F complex can directly contact eIF3 in the 43S complex. eIF1A is necessary for the formation of this complex.

Literature References
PubMed ID Title Journal Year
6853548 New initiation factor activity required for globin mRNA translation.

Tahara, SM, Morgan, MA, Grifo, JA, Merrick, WC, Shatkin, AJ

J Biol Chem 1983
592399 Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors.

Erni, B, Schreier, MH, Trachsel, H, Staehelin, T

J Mol Biol 1978
641056 The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.

Benne, R, Hershey, JW

J Biol Chem 1978
9732867 Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.

Hellen, CU, Pestova, TV, Borukhov, SI

Nature 1999
Participants
Input
Output
Participates
as an event of
Orthologous Events
Formation of translation initiation complexes containing mRNA that does not circularize (Bos taurus)
Formation of translation initiation complexes containing mRNA that does not circularize (Caenorhabditis elegans)
Formation of translation initiation complexes containing mRNA that does not circularize (Canis familiaris)
Formation of translation initiation complexes containing mRNA that does not circularize (Danio rerio)
Formation of translation initiation complexes containing mRNA that does not circularize (Drosophila melanogaster)
Formation of translation initiation complexes containing mRNA that does not circularize (Mus musculus)
Formation of translation initiation complexes containing mRNA that does not circularize (Rattus norvegicus)
Formation of translation initiation complexes containing mRNA that does not circularize (Saccharomyces cerevisiae)
Formation of translation initiation complexes containing mRNA that does not circularize (Sus scrofa)
Created
Merrick, WC  (2002-12-16)
Cite Us!