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About
What is Reactome ?
News
Team
Scientific Advisory Board
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Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
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COVID-19 Disease Pathways
Docs
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Pathway Browser
How do I search ?
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RAE1 [nuclear envelope]
Stable Identifier
R-HSA-157718
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nuclear envelope
Synonyms
Rae1/Gle2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Nuclear Envelope Breakdown (Homo sapiens)
Nuclear Pore Complex (NPC) Disassembly (Homo sapiens)
CDK1 phosphorylates NUP98 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (p-2S,3T-NUP98) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
NEK6/NEK7 phosphorylates NUP98 (Homo sapiens)
Nuclear Pore Complex (p-2S,3T-NUP98) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Partially Disassembled NPC [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
HSF1 activation (Homo sapiens)
HSF1 trimer translocates to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) (Homo sapiens)
Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)
Defective NPC [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Early Events (Homo sapiens)
HCMV Nuclear Pore Docking (Homo sapiens)
HCMV Capsid:Nuclear Pore Complex [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Transport of HCMV DNA Into the Nucleus (Homo sapiens)
HCMV Capsid:Nuclear Pore Complex [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
HCMV Late Events (Homo sapiens)
Translocation of SCP, Triplex (TRI) complex, CVC complex, and Accessory Proteins from the cytoplasm into the nucleous (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Transport of MCP:pPR-AP:pAP Complex into the Nucleous (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Translocation of nuclear RNA transport complex to cytoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Interactions of Rev with host cellular proteins (Homo sapiens)
Nuclear import of Rev protein (Homo sapiens)
Rev:importin beta:B23 recruited to the nuclear pore (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
nucleoporin-associated Rev:Importin-beta:B23 complex [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Translocation of Rev:importin-beta:B23 to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
nucleoporin-associated Rev:Importin-beta:B23 complex [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Translocation of nuclear RNA transport complex to cytoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Interactions of Vpr with host cellular proteins (Homo sapiens)
Vpr-mediated nuclear import of PICs (Homo sapiens)
Vpr binds nucleoporins (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
PIC anchored to the NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Influenza Infection (Homo sapiens)
Export of Viral Ribonucleoproteins from Nucleus (Homo sapiens)
NEP/NS2 Interacts with the Cellular Export Machinery (Homo sapiens)
vRNP Export through the nuclear pore (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Influenza Viral RNA Transcription and Replication (Homo sapiens)
Viral Messenger RNA Synthesis (Homo sapiens)
Export of Spliced Viral mRNA (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Viral mRNA Export (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
NS1 Mediated Effects on Host Pathways (Homo sapiens)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Transport of Ribonucleoproteins into the Host Nucleus (Homo sapiens)
Docking and transport of the RNP:Karyopherin complex through the nuclear pore (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Dimerized phospho-IRF3, IRF7 is transported to the nucleus (Homo sapiens)
6:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
SARS-CoV-2 6 binds NUP98:RAE1 within NPC (Homo sapiens)
6:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
Transcriptional regulation by small RNAs (Homo sapiens)
Importin-8 imports AGO2:miRNA into the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Translocation of ISGF3 complex to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Translocation of p-STAT1:p-STAT1 dimer to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Homo sapiens)
NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (Homo sapiens)
Beta-catenin migrates to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
IRF3-mediated induction of type I IFN (Homo sapiens)
Dimerized phospho-IRF3 migrates to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
IRF3 mediated activation of type 1 IFN (Homo sapiens)
Dimerized phospho-IRF3 migrates to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
Regulation of Glucokinase by Glucokinase Regulatory Protein (Homo sapiens)
NPC transports GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Metabolism of non-coding RNA (Homo sapiens)
snRNP Assembly (Homo sapiens)
Nuclear export of snRNA transcripts (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
snRNP nuclear import and release (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Transport of Mature mRNAs Derived from Intronless Transcripts (Homo sapiens)
Transport of Mature mRNA Derived from an Intronless Transcript (Homo sapiens)
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Transport of the SLBP Dependant Mature mRNA (Homo sapiens)
Docking of Mature Replication Dependent Histone mRNA with the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Transport of the SLBP independent Mature mRNA (Homo sapiens)
Docking of Mature Histone mRNA complex:TAP at the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Release of the SLBP independent Histone mRNA from the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
tRNA processing (Homo sapiens)
tRNA processing in the nucleus (Homo sapiens)
tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
RANBP2 SUMOylates PML with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
RANBP2 SUMOylates PML with SUMO2 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
RANBP2 SUMOylates SP100 with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
RANBP2 SUMOylates SP100 with SUMO2 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
SUMOylation of DNA replication proteins (Homo sapiens)
RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens)
RANBP2:RANGAP1-SUMO1:UBE2I:Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
RANBP2 SUMOylates TOP2A with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
SUMOylation of RNA binding proteins (Homo sapiens)
RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
SUMOylation of SUMOylation proteins (Homo sapiens)
RANBP2 SUMOylates RANBP2 with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
RANBP2 SUMOylates RANBP2 with SUMO2 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
RANBP2 SUMOylates HDAC4 with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
RANBP2 SUMOylates HDAC4 with SUMO2,3 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
SUMOylation of ubiquitinylation proteins (Homo sapiens)
RANBP2 SUMOylates MDM2 with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
RAE1 [nuclear envelope] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78406 RAE1
Gene Names
RAE1, MRNP41
Chain
chain:1-368
Reference Genes
BioGPS Gene:8480 RAE1
COSMIC (genes):RAE1 RAE1
CTD Gene:8480 RAE1
dbSNP Gene:8480 RAE1
ENSEMBL:ENSG00000101146 RAE1
ENSEMBL_homo_sapiens_GENE:ENSG00000101146.13 RAE1
HGNC:9828 RAE1
KEGG Gene (Homo sapiens):8480 RAE1
Monarch:8480 RAE1
NCBI Gene:8480 RAE1
OMIM:603343 RAE1
UCSC:P78406 RAE1
Reference Transcript
RefSeq:NM_001015885.1 RAE1
RefSeq:XM_005260582.2 RAE1
RefSeq:XM_011529088.2 RAE1
RefSeq:NM_003610.3 RAE1
RefSeq:XM_005260583.2 RAE1
RefSeq:XM_011529089.1 RAE1
Other Identifiers
11716235_a_at
11716236_s_at
16915151
201558_PM_at
201558_at
211318_PM_s_at
211318_s_at
32757_at
32758_g_at
3890556
3890557
3890558
3890559
3890560
3890562
3890564
3890568
3890570
3890572
3890574
3890578
3890581
3890582
3890588
3890589
3890590
3890592
3890594
48245_at
8063566
8480
A_23_P346206
A_23_P6023
A_33_P3443165
GE510848
GE62247
GE87667
GO:0000278
GO:0000922
GO:0000972
GO:0001650
GO:0003723
GO:0005515
GO:0005634
GO:0005635
GO:0005643
GO:0005654
GO:0005730
GO:0005737
GO:0005856
GO:0006405
GO:0006406
GO:0006913
GO:0007010
GO:0007049
GO:0008017
GO:0008092
GO:0043130
GO:0043226
GO:0051301
GO:0060236
GO:0071407
GO:0097431
HMNXSV003041234
ILMN_1690259
ILMN_1781454
ILMN_2295042
PH_hs_0024189
TC20000448.hg
U84720_at
g2231591_3p_a_at
g4506398_3p_at
Participates
as a component of
RANBP2:RANGAP1-SUMO1:UBE2I:Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
Defective NPC [nuclear envelope] (Homo sapiens)
Partially Disassembled NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (p-2S,3T-NUP98) [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
Inferred To
RAE1 [nuclear envelope]
(Bos taurus)
RAE1 [nuclear envelope]
(Gallus gallus)
RAE1 [nuclear envelope]
(Sus scrofa)
Ghost homologue of RAE1 [nuclear envelope]
(Canis familiaris)
rae-1 [nuclear envelope]
(Caenorhabditis elegans)
GLE2 [nuclear envelope]
(Saccharomyces cerevisiae)
rae1 [nuclear envelope]
(Schizosaccharomyces pombe)
rae1 [nuclear envelope]
(Xenopus tropicalis)
Rae1 [nuclear envelope]
(Drosophila melanogaster)
Rae1 [nuclear envelope]
(Mus musculus)
Rae1 [nuclear envelope]
(Rattus norvegicus)
Cross References
RefSeq
XP_005260639.2
,
NP_001015885.1
,
XP_011527390.1
,
XP_005260640.1
,
XP_011527391.1
,
NP_003601.1
OpenTargets
ENSG00000101146
HPA
ENSG00000101146-RAE1
GeneCards
P78406
Ensembl
ENST00000371242
,
ENST00000395841
,
ENST00000395840
,
ENSP00000379181
,
ENSP00000360286
,
ENSP00000379182
,
ENSG00000101146
PRO
P78406
Pharos - Targets
P78406
PDB
7VPG
,
4OWR
,
3MMY
,
7F90
,
7VPH
,
7F60
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC6 6
4
6 [nuclear envelope]
(R-COV-9727279)
6 [cytosol]
(R-COV-9708916)
6 [endoplasmic reticulum membrane]
(R-COV-9727295)
6 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9705293)
0.928
11
UniProt:P59634 6
2
6 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9705957)
6 [cytosol]
(R-COV-9731048)
0.784
5
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
4
UniProt:Q80U93
2
Nup214 [nucleoplasm]
(R-MMU-451222)
Nup214 [cytosol]
(R-MMU-157691)
0.564
2
UniProt:Q9UBU9 NXF1
2
NXF1 [cytosol]
(R-HSA-156481)
NXF1 [nucleoplasm]
(R-HSA-111690)
0.544
2
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