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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
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How do I search ?
Details Panel
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NUP214 [cytosol]
Stable Identifier
R-HSA-157691
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Nup214
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Nuclear Envelope Breakdown (Homo sapiens)
Nuclear Pore Complex (NPC) Disassembly (Homo sapiens)
CDK1 phosphorylates NUP98 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Nuclear Pore Complex (p-2S,3T-NUP98) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
NEK6/NEK7 phosphorylates NUP98 (Homo sapiens)
Nuclear Pore Complex (p-2S,3T-NUP98) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Partially Disassembled NPC [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
HSF1 activation (Homo sapiens)
HSF1 trimer translocates to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) (Homo sapiens)
Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)
Defective NPC [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Early Events (Homo sapiens)
HCMV Nuclear Pore Docking (Homo sapiens)
HCMV Capsid:Nuclear Pore Complex [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Transport of HCMV DNA Into the Nucleus (Homo sapiens)
HCMV Capsid:Nuclear Pore Complex [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
HCMV Late Events (Homo sapiens)
Translocation of SCP, Triplex (TRI) complex, CVC complex, and Accessory Proteins from the cytoplasm into the nucleous (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Transport of MCP:pPR-AP:pAP Complex into the Nucleous (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Translocation of nuclear RNA transport complex to cytoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Interactions of Rev with host cellular proteins (Homo sapiens)
Nuclear import of Rev protein (Homo sapiens)
Rev:importin beta:B23 recruited to the nuclear pore (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
nucleoporin-associated Rev:Importin-beta:B23 complex [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Translocation of Rev:importin-beta:B23 to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
nucleoporin-associated Rev:Importin-beta:B23 complex [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Translocation of nuclear RNA transport complex to cytoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Interactions of Vpr with host cellular proteins (Homo sapiens)
Vpr-mediated nuclear import of PICs (Homo sapiens)
Vpr binds nucleoporins (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
PIC anchored to the NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Influenza Infection (Homo sapiens)
Export of Viral Ribonucleoproteins from Nucleus (Homo sapiens)
NEP/NS2 Interacts with the Cellular Export Machinery (Homo sapiens)
vRNP Export through the nuclear pore (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Influenza Viral RNA Transcription and Replication (Homo sapiens)
Viral Messenger RNA Synthesis (Homo sapiens)
Export of Spliced Viral mRNA (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Viral mRNA Export (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
NS1 Mediated Effects on Host Pathways (Homo sapiens)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Transport of Ribonucleoproteins into the Host Nucleus (Homo sapiens)
Docking and transport of the RNP:Karyopherin complex through the nuclear pore (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Dimerized phospho-IRF3, IRF7 is transported to the nucleus (Homo sapiens)
6:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
SARS-CoV-2 6 binds NUP98:RAE1 within NPC (Homo sapiens)
6:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
Transcriptional regulation by small RNAs (Homo sapiens)
Importin-8 imports AGO2:miRNA into the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Translocation of ISGF3 complex to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Translocation of p-STAT1:p-STAT1 dimer to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Homo sapiens)
NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (Homo sapiens)
Beta-catenin migrates to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
IRF3-mediated induction of type I IFN (Homo sapiens)
Dimerized phospho-IRF3 migrates to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
IRF3 mediated activation of type 1 IFN (Homo sapiens)
Dimerized phospho-IRF3 migrates to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
Regulation of Glucokinase by Glucokinase Regulatory Protein (Homo sapiens)
NPC transports GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Metabolism of non-coding RNA (Homo sapiens)
snRNP Assembly (Homo sapiens)
Nuclear export of snRNA transcripts (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
snRNP nuclear import and release (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Transport of Mature mRNAs Derived from Intronless Transcripts (Homo sapiens)
Transport of Mature mRNA Derived from an Intronless Transcript (Homo sapiens)
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Transport of the SLBP Dependant Mature mRNA (Homo sapiens)
Docking of Mature Replication Dependent Histone mRNA with the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Transport of the SLBP independent Mature mRNA (Homo sapiens)
Docking of Mature Histone mRNA complex:TAP at the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Release of the SLBP independent Histone mRNA from the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
tRNA processing (Homo sapiens)
tRNA processing in the nucleus (Homo sapiens)
tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
RANBP2 SUMOylates PML with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
RANBP2 SUMOylates PML with SUMO2 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
RANBP2 SUMOylates SP100 with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
RANBP2 SUMOylates SP100 with SUMO2 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
SUMOylation of DNA replication proteins (Homo sapiens)
RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens)
RANBP2:RANGAP1-SUMO1:UBE2I:Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
RANBP2 SUMOylates TOP2A with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
SUMOylation of RNA binding proteins (Homo sapiens)
RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
SUMOylation of SUMOylation proteins (Homo sapiens)
RANBP2 SUMOylates RANBP2 with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
RANBP2 SUMOylates RANBP2 with SUMO2 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
RANBP2 SUMOylates HDAC4 with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
RANBP2 SUMOylates HDAC4 with SUMO2,3 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
SUMOylation of ubiquitinylation proteins (Homo sapiens)
RANBP2 SUMOylates MDM2 with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
NUP214 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35658 NUP214
Gene Names
NUP214, CAIN, CAN, KIAA0023
Chain
initiator methionine:, chain:2-2090
Reference Genes
BioGPS Gene:8021 NUP214
COSMIC (genes):NUP214 NUP214
CTD Gene:8021 NUP214
dbSNP Gene:8021 NUP214
ENSEMBL:ENSG00000126883 NUP214
HGNC:8064 NUP214
KEGG:hsa:8021 NUP214
Monarch:8021 NUP214
NCBI Gene:8021 NUP214
OMIM:114350 NUP214
UCSC:P35658 NUP214
Reference Transcript
RefSeq:NM_001318324.1 NUP214
RefSeq:NM_001318325.1 NUP214
RefSeq:NM_005085.3 NUP214
Other Identifiers
11747425_a_at
11750555_a_at
11752614_a_at
11758849_at
17090444
202155_PM_s_at
202155_s_at
211261_PM_at
211261_at
228902_PM_at
228902_at
3191901
3191902
3191903
3191905
3191906
3191907
3191908
3191909
3191910
3191911
3191912
3191913
3191917
3191918
3191919
3191920
3191921
3191922
3191923
3191924
3191925
3191926
3191927
3191928
3191929
3191931
3191932
3191933
3191934
3191936
3191937
3191938
3191939
3191940
3191941
3191942
3191943
3191944
3191945
3191947
3191948
3191949
3191950
3191951
3191952
3191953
3191954
3191955
3191956
3191957
3191958
3191959
3191960
3191961
3191962
3191963
3191964
3191965
3191975
3191977
3191983
3191984
3191985
3191986
3191987
3191988
3191989
3191990
3191993
3191994
3191995
3191996
3191997
3191998
3191999
3192000
3192001
3192002
3192003
3192004
3192005
40768_s_at
40769_r_at
54602_at
8021
8158783
A_14_P114993
A_14_P125787
A_14_P132180
A_23_P257091
D14689_at
GE57087
GO:0005049
GO:0005198
GO:0005515
GO:0005634
GO:0005635
GO:0005643
GO:0005654
GO:0005829
GO:0006405
GO:0006406
GO:0006606
GO:0006611
GO:0006886
GO:0006913
GO:0008139
GO:0015031
GO:0017056
GO:0043226
GO:0046822
GO:0051028
GO:0051726
GO:0140104
GO:1990876
HMNXSV003048536
Hs.170285.2.S1_3p_at
ILMN_1666049
PH_hs_0026405
TC09000746.hg
g285956_3p_a_at
Participates
as a component of
RANBP2:RANGAP1-SUMO1:UBE2I:Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
Defective NPC [nuclear envelope] (Homo sapiens)
Partially Disassembled NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (p-2S,3T-NUP98) [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
Other forms of this molecule
NUP214 [nucleoplasm]
Inferred To
nup214 [cytosol]
(Xenopus tropicalis)
NUP214 [cytosol]
(Bos taurus)
NUP214 [cytosol]
(Canis familiaris)
NUP214 [cytosol]
(Gallus gallus)
NUP214 [cytosol]
(Sus scrofa)
nup124 [cytosol]
(Schizosaccharomyces pombe)
NUP1 [cytosol]
(Saccharomyces cerevisiae)
Nup214 [cytosol]
(Drosophila melanogaster)
Nup214 [cytosol]
(Mus musculus)
Nup214 [cytosol]
(Rattus norvegicus)
Ghost homologue of NUP214 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_005076.3
,
NP_001305253.1
,
NP_001305254.1
ENSEMBL
ENSP00000396576
,
ENST00000359428
,
ENST00000411637
,
ENSP00000352400
OpenTargets
ENSG00000126883
HPA
ENSG00000126883-NUP214
PRO
P35658
Pharos - Targets
P35658
GlyGen
P35658
Orphanet
NUP214
PDB
3FHC
,
7R5J
,
7R5K
,
2OIT
,
3FMO
,
5DIS
,
3FMP
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UBU9 NXF1
2
NXF1 [nucleoplasm]
(R-HSA-111690)
NXF1 [cytosol]
(R-HSA-156481)
0.759
4
UniProt:Q99567 NUP88
1
NUP88 [cytosol]
(R-HSA-157753)
0.669
4
UniProt:P0DTD1-PRO_0000449627 REP
0.527
2
UniProt:Q13283 G3BP1
1
G3BP1 [cytosol]
(R-HSA-9729517)
0.527
2
UniProt:P62826 RAN
2
RAN [cytosol]
(R-HSA-165540)
RAN [nucleoplasm]
(R-HSA-165528)
0.527
4
UniProt:Q9UN86 G3BP2
1
G3BP2 [cytosol]
(R-HSA-9729507)
0.527
2
UniProt:P37198 NUP62
2
NUP62 [nuclear envelope]
(R-HSA-157713)
NUP62 [cytosol]
(R-HSA-9634226)
0.527
3
UniProt:P51116 FXR2
0.483
2
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