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JAG2 [plasma membrane]
Stable Identifier
R-HSA-157120
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Jagged 2 ligand
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD Domain Mutants (Homo sapiens)
NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding (Homo sapiens)
NOTCH1 HD domain mutant fragments/Ub-DLL/JAG:NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 HD Domain Mutant Fragments [extracellular region] (Homo sapiens)
DLL/JAG:NOTCH1 HD Domain Mutant Fragments [extracellular region] (Homo sapiens)
JAG2:NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
NOTCH1 HD domain mutants/Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
NOTCH1 HD domain mutants bind JAG2 (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants (Homo sapiens)
DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding (Homo sapiens)
NOTCH1 HD+PEST Domain Mutant Fragments/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
NOTCH1 HD+PEST Domain Mutants/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
NOTCH1 HD+PEST domain mutants bind JAG2 (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants (Homo sapiens)
DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants (Homo sapiens)
Ub-DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 fragment [plasma membrane] (Homo sapiens)
NOTCH1 fragment:DLL/JAG [plasma membrane] (Homo sapiens)
DLL/JAG [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
NOTCH1 PEST domain mutants bind JAG2 (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants (Homo sapiens)
DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (Homo sapiens)
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (Homo sapiens)
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2 (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)
Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 (Homo sapiens)
Ub-DLL/JAG:NOTCH1 [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 fragment [plasma membrane] (Homo sapiens)
NOTCH1 fragment:DLL/JAG [plasma membrane] (Homo sapiens)
DLL/JAG [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
NOTCH1 binds DLL/JAG ligand in cis (Homo sapiens)
DLL/JAG [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
NOTCH1:DLL/JAG [plasma membrane] (Homo sapiens)
DLL/JAG [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
NOTCH1 binds JAG2 (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 (Homo sapiens)
DLL/JAG:NOTCH1 [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Signaling by NOTCH2 (Homo sapiens)
NOTCH2 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
JAG2 binds NOTCH2 (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
JAG2:NOTCH2 [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
NOTCH2 binds DLL/JAG ligand in cis (Homo sapiens)
DLL/JAG [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
NOTCH2:DLL/JAG [plasma membrane] (Homo sapiens)
DLL/JAG [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
NOTCH2-ligand complex is cleaved to produce NEXT2 (Homo sapiens)
NOTCH2 fragment:DLL/JAG [plasma membrane] (Homo sapiens)
DLL/JAG [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH2 [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH2 [plasma membrane] (Homo sapiens)
JAG2:NOTCH2 [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
NOTCH2NLB, (NOTCH2NLA, NOTCH2NLC) bind DLL1, (DLL4, JAG1, JAG2) (Homo sapiens)
DLL1, (DLL4, JAG1, JAG2) [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
NOTCH2NLB,(NOTCH2NLA,NOTCH2NLC):DLL1, (DLL4, JAG1, JAG2) [plasma membrane] (Homo sapiens)
DLL1, (DLL4, JAG1, JAG2) [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 (Homo sapiens)
DLL/JAG:NOTCH2 [plasma membrane] (Homo sapiens)
JAG2:NOTCH2 [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH2 [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH2 [plasma membrane] (Homo sapiens)
JAG2:NOTCH2 [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
NOTCH3 binds JAG2 (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
JAG2:NOTCH3 [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 (Homo sapiens)
DLL/JAG:NOTCH3 [plasma membrane] (Homo sapiens)
JAG2:NOTCH3 [plasma membrane] (Homo sapiens)
JAG2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y219 JAG2
Gene Names
JAG2
Chain
signal peptide:1-23, chain:24-1238
Reference Genes
BioGPS Gene:3714 JAG2
COSMIC (genes):JAG2 JAG2
CTD Gene:3714 JAG2
dbSNP Gene:3714 JAG2
ENSEMBL:ENSG00000184916 JAG2
HGNC:6189 JAG2
KEGG:hsa:3714 JAG2
Monarch:3714 JAG2
NCBI Gene:3714 JAG2
OMIM:602570 JAG2
UCSC:Q9Y219 JAG2
Reference Transcript
RefSeq:NM_002226.4 JAG2
RefSeq:NM_145159.2 JAG2
Other Identifiers
11723896_a_at
16797241
209784_PM_s_at
209784_s_at
32137_3p_at
32137_PM_at
32137_at
3581441
3581443
3581444
3581445
3581446
3581447
3581448
3581449
3581451
3581452
3581453
3581454
3581455
3581456
3581457
3581458
3581459
3581460
3581461
3581463
3581465
3581466
3581467
3581468
3581469
3581470
3581471
3581472
3581473
3581474
3581475
3581477
3581478
3581479
3581481
3581482
3581483
3581484
3714
4864910_3p_at
7981538
80131_at
A_23_P106024
GE81132
GO:0001501
GO:0001701
GO:0002376
GO:0003016
GO:0005112
GO:0005509
GO:0005515
GO:0005886
GO:0007154
GO:0007219
GO:0007275
GO:0007283
GO:0008083
GO:0009912
GO:0012501
GO:0016020
GO:0016331
GO:0022414
GO:0030154
GO:0030155
GO:0030217
GO:0042127
GO:0042475
GO:0042492
GO:0045061
GO:0045747
GO:0048018
GO:0048856
GO:0098772
GO:1990134
HMNXSV003036654
HMNXSV003053247
ILMN_1658925
ILMN_1764729
ILMN_2399523
PH_hs_0025282
TC14002333.hg
g2605944_3p_a_at
g2605944_3p_s_at
p33411
Participates
as a component of
JAG2:NOTCH1 [plasma membrane] (Homo sapiens)
JAG2:NOTCH3 [plasma membrane] (Homo sapiens)
JAG2:NOTCH2 [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
as an input of
NOTCH1 binds JAG2 (Homo sapiens)
NOTCH3 binds JAG2 (Homo sapiens)
JAG2 binds NOTCH2 (Homo sapiens)
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2 (Homo sapiens)
NOTCH1 PEST domain mutants bind JAG2 (Homo sapiens)
NOTCH1 HD+PEST domain mutants bind JAG2 (Homo sapiens)
NOTCH1 HD domain mutants bind JAG2 (Homo sapiens)
as a member of
DLL/JAG [plasma membrane] (Homo sapiens)
as a candidate of
DLL1, (DLL4, JAG1, JAG2) [plasma membrane] (Homo sapiens)
Other forms of this molecule
Ub-JAG2 [plasma membrane]
Inferred To
Jag2 [plasma membrane]
(Mus musculus)
Jag2 [plasma membrane]
(Rattus norvegicus)
JAG2 [plasma membrane]
(Bos taurus)
JAG2 [plasma membrane]
(Gallus gallus)
JAG2 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_660142.1
,
NP_002217.3
ENSEMBL
ENST00000347004
,
ENST00000331782
,
ENSP00000328566
,
ENSP00000328169
OpenTargets
ENSG00000184916
HPA
ENSG00000184916-JAG2
PRO
Q9Y219
Pharos - Targets
Q9Y219
GlyGen
Q9Y219
PDB
5MW7
,
5MW5
,
5MWF
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5VTD9 GFI1B
0.508
2
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