Reactome | JAG1 [plasma membrane]

JAG1 [plasma membrane]

Stable Identifier

R-HSA-157098

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Jagged 1 ligand

Icon

Locations in the PathwayBrowser for interactor UniProt:P46531 NOTCH1

Expand all

External Reference Information

External Reference

UniProt:P78504 JAG1

Gene Names

JAG1, JAGL1

Chain

signal peptide:1-33, chain:34-1218

Reference Genes

BioGPS Gene:182 JAG1

COSMIC (genes):JAG1 JAG1

CTD Gene:182 JAG1

dbSNP Gene:182 JAG1

ENSEMBL:ENSG00000101384 JAG1

ENSEMBL_homo_sapiens_GENE:ENSG00000101384.12 JAG1

HGNC:6188 JAG1

KEGG Gene (Homo sapiens):182 JAG1

Monarch:182 JAG1

NCBI Gene:182 JAG1

OMIM:601920 JAG1

UCSC:P78504 JAG1

Reference Transcript

Other Identifiers

11720823_at

11720824_a_at

11720825_s_at

11720826_s_at

11751993_a_at

11751994_s_at

16917183

182

209097_3p_s_at

209097_PM_s_at

209097_s_at

209098_PM_s_at

209098_s_at

209099_PM_x_at

209099_x_at

216268_PM_s_at

216268_s_at

33178_at

35414_s_at

3897506

3897507

3897508

3897509

3897510

3897511

3897512

3897514

3897515

3897516

3897517

3897518

3897519

3897520

3897522

3897527

3897529

3897531

3897533

3897535

3897536

3897537

3897539

3897540

3897543

3897544

3897550

3897552

3897555

3897558

3897559

3897560

3897568

3897587

3897588

3897589

3897590

74827_s_at

8064978

A_23_P210763

GE54053

GO:0001525

GO:0001709

GO:0001953

GO:0001974

GO:0002011

GO:0002085

GO:0002376

GO:0002456

GO:0003180

GO:0003184

GO:0003215

GO:0005112

GO:0005198

GO:0005509

GO:0005515

GO:0005543

GO:0005576

GO:0005886

GO:0005912

GO:0006351

GO:0006355

GO:0007154

GO:0007155

GO:0007219

GO:0007275

GO:0007399

GO:0008083

GO:0008289

GO:0009887

GO:0016020

GO:0016324

GO:0022408

GO:0022414

GO:0023052

GO:0030097

GO:0030154

GO:0030182

GO:0030216

GO:0030336

GO:0032495

GO:0035909

GO:0042127

GO:0042491

GO:0043010

GO:0045177

GO:0045445

GO:0045446

GO:0045599

GO:0045602

GO:0045639

GO:0045665

GO:0045669

GO:0045747

GO:0045944

GO:0048018

GO:0048839

GO:0048856

GO:0048870

GO:0050678

GO:0060090

GO:0060411

GO:0061073

GO:0061101

GO:0061156

GO:0061309

GO:0061444

GO:0062043

GO:0072006

GO:0072015

GO:0072017

GO:0072070

GO:0097150

GO:0098772

GO:2000241

GO:2000737

HMNXSV003051006

Hs.91143.0.A1_3p_a_at

Hs.91143.0.A1_3p_at

ILMN_1691376

PH_hs_0024786

TC20000621.hg

TC20001421.hg

U61276_s_at

U73936_at

g1438936_3p_a_at

g1695273_3p_a_at

Participates

as a component of

as an input of

as an output of

as a member of

DLL/JAG [plasma membrane] (Homo sapiens)

as a candidate of

Other forms of this molecule

Ub-JAG1 [plasma membrane]

Inferred To

JAG1 [plasma membrane] (Bos taurus)

JAG1 [plasma membrane] (Canis familiaris)

JAG1 [plasma membrane] (Gallus gallus)

JAG1 [plasma membrane] (Sus scrofa)

jag1b [plasma membrane] (Danio rerio)

Jag1 [plasma membrane] (Mus musculus)

Jag1 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_000205.1, XP_016883196.1

OpenTargets

ENSG00000101384

GeneCards

P78504

HPA

ENSG00000101384-JAG1

Ensembl

ENSP00000254958, ENSG00000101384, ENST00000254958

PRO

P78504

Pharos - Targets

P78504

Orphanet

16278

PDB

2KB9, 4CBZ, 4CC1, 4CC0, 5BO1, 2VJ2, 4XI7

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.728	6
UniProt:P15529 CD46	1	CD46 [plasma membrane] (R-HSA-977362)	0.632	5