Aminoacyl-tRNA binds to the ribosome at the A-site

Stable Identifier
R-HSA-156907
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Once the correct codon-anticodon match occurs between the mRNA and aa-tRNA, the decoding event triggers GTP hydrolysis on eEF1A. The resulting conformational change releases the aa-tRNA to the A-site, and GDP bound form eEF1A is released from the ribosome.
Insight into the mechanics of this system has been obtained from earlier works with rabbit reticulocytes and the E.coli system.
This process is illustrated below with: an amino acyl-tRNA with an amino acid, a peptidyl-tRNA with a growing peptide and a ribosome with A,P and E sites to accommodate these two forms of tRNA.

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