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EEF1A1 [cytosol]
Stable Identifier
R-HSA-156905
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eEF1A
Icon
Locations in the PathwayBrowser for interactor UniProt:Q14166 TTLL12
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
HSF1 activation (Homo sapiens)
Trimerization of cytosolic HSF1 (Homo sapiens)
EEF1A1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 modulates host translation machinery (Homo sapiens)
SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to EEF1A1 (Homo sapiens)
EEF1A1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein methylation (Homo sapiens)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Homo sapiens)
EEF1A1 [cytosol] (Homo sapiens)
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Homo sapiens)
EEF1A1 [cytosol] (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Elongation (Homo sapiens)
eEF1A complexes with GTP (Homo sapiens)
EEF1A1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P68104 EEF1A1
Gene Names
EEF1A1, EEF1A, EF1A, LENG7
Chain
initiator methionine:, chain:2-462
Reference Genes
BioGPS Gene:1915 EEF1A1
COSMIC (genes):EEF1A1 EEF1A1
CTD Gene:1915 EEF1A1
dbSNP Gene:1915 EEF1A1
ENSEMBL:ENSG00000156508 EEF1A1
ENSEMBL_homo_sapiens_GENE:ENSG00000156508.19 EEF1A1
HGNC:3189 EEF1A1
KEGG Gene (Homo sapiens):1915 EEF1A1
Monarch:1915 EEF1A1
NCBI Gene:1915 EEF1A1
OMIM:130590 EEF1A1
Reference Transcript
RefSeq:XM_011535514.2 EEF1A1
RefSeq:NM_001402.5 EEF1A1
Other Identifiers
11736052_at
11736053_x_at
11745648_x_at
11747077_x_at
11749754_a_at
11758011_x_at
11763055_x_at
1288_s_at
17020802
17124688
1915
204892_PM_x_at
204892_x_at
206559_PM_x_at
206559_x_at
213477_PM_x_at
213477_x_at
213583_PM_x_at
213583_x_at
213614_PM_x_at
213614_x_at
227708_PM_at
227708_at
2348021
2348024
2348025
2348032
2348034
2373154
2569187
2569193
2708373
2708375
2738235
2738237
2744059
2778490
2849416
2849418
2849420
2855646
2855648
2855656
2855660
2855664
2960904
2960905
2960906
2960907
2960908
2960909
2960910
2960911
2960912
2960913
2960915
2960916
2960918
2960919
2960920
2960923
2960925
2960926
2960928
2960929
2960930
2960933
2960934
2960935
2960936
2960937
2960938
2960939
2960940
2960941
2960942
2960943
2960944
2960945
2960946
2960947
2960948
2960949
3041173
3041175
3041176
3041177
3041178
3041181
3041182
3041183
3041184
3041185
3041186
3041187
3192641
3192642
3192643
3192644
3192645
3192647
3192648
3192649
3192650
3192651
3192652
3412272
3446487
3466940
3483213
3624916
40886_at
40887_g_at
57355_f_at
60075_f_at
68493_r_at
8127544
8138531
8158952
91422_at
A_24_P763243
A_32_P47701
GE79868
GO:0000049
GO:0000166
GO:0003723
GO:0003746
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005634
GO:0005730
GO:0005737
GO:0005764
GO:0005773
GO:0005829
GO:0005840
GO:0005853
GO:0005856
GO:0005886
GO:0006412
GO:0006414
GO:0006914
GO:0016020
GO:0016787
GO:0019900
GO:0019901
GO:0022626
GO:0030163
GO:0030864
GO:0031410
GO:0032587
GO:0034774
GO:0043226
GO:0044829
GO:0045182
GO:0060090
GO:0070062
GO:0071364
GO:0098574
GO:1900022
GO:1904714
GO:1904813
Hs.181165.6.A1_3p_at
Hs.284136.2.S1_3p_x_at
ILMN_1343291
ILMN_1810810
ILMN_2038774
J04617_s_at
PH_hs_0030265
TC06001875.hg
TC06003716.hg
TC07002822.hg
TC09002314.hg
X03689_s_at
g4503470_3p_x_at
Participates
as an input of
N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Homo sapiens)
METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Homo sapiens)
eEF1A complexes with GTP (Homo sapiens)
SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to EEF1A1 (Homo sapiens)
as a member of
EEF1A1-like proteins [cytosol] (Homo sapiens)
as a component of
eEF1A:GTP [cytosol] (Homo sapiens)
eEF1A:GDP [cytosol] (Homo sapiens)
EEF1A1:SUMO1-K62-p-S177-Ncap dimer [cytosol] (Homo sapiens)
EEF1A1:GTP [cytosol] (Homo sapiens)
This entity regulates
Positively
Trimerization of cytosolic HSF1
(Homo sapiens)
Other forms of this molecule
Me3K79-EEF1A1 [cytosol]
Me3K318-EEF1A1 [cytosol]
EEF1A1 [secretory granule lumen]
EEF1A1 [extracellular region]
EEF1A1 [ficolin-1-rich granule lumen]
EEF1A1 [lysosomal membrane]
Inferred To
Homologues of EEF1A1 [cytosol]
(Canis familiaris)
Homologues of EEF1A1 [cytosol]
(Dictyostelium discoideum)
Homologues of EEF1A1 [cytosol]
(Drosophila melanogaster)
Homologues of EEF1A1 [cytosol]
(Plasmodium falciparum)
Homologues of EEF1A1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of EEF1A1 [cytosol]
(Schizosaccharomyces pombe)
eef1a1a [cytosol]
(Danio rerio)
eef1a1 [cytosol]
(Xenopus tropicalis)
EEF1A1 [cytosol]
(Bos taurus)
EEF1A1 [cytosol]
(Caenorhabditis elegans)
EEF1A1 [cytosol]
(Canis familiaris)
EEF1A1 [cytosol]
(Dictyostelium discoideum)
EEF1A1 [cytosol]
(Drosophila melanogaster)
EEF1A1 [cytosol]
(Gallus gallus)
EEF1A1 [cytosol]
(Mus musculus)
EEF1A1 [cytosol]
(Plasmodium falciparum)
EEF1A1 [cytosol]
(Rattus norvegicus)
EEF1A1 [cytosol]
(Saccharomyces cerevisiae)
EEF1A1 [cytosol]
(Schizosaccharomyces pombe)
EEF1A1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001393.1
,
XP_011533816.1
OpenTargets
ENSG00000156508
HPA
ENSG00000156508-EEF1A1
ZINC - Substances
EF1A1_HUMAN
GeneCards
P68104
ZINC target
P68104
Ensembl
ENST00000676710
,
ENST00000677236
,
ENSP00000339063
,
ENSP00000503192
,
ENSP00000339053
,
ENST00000678702
,
ENST00000331523
,
ENSP00000503823
,
ENSP00000503249
,
ENST00000455918
,
ENST00000356303
,
ENST00000678508
,
ENSG00000156508
,
ENST00000316292
,
ENST00000309268
,
ENST00000615060
,
ENSP00000479055
,
ENSP00000348651
,
ENSP00000330054
,
ENSP00000504335
,
ENSP00000392366
PRO
P68104
Pharos - Targets
P68104
ZINC - Predictions - Purchasable
EF1A1_HUMAN
HMDB Protein
HMDBP01875
PDB
6ZMO
,
3C5J
,
8G6J
,
8G60
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14166 TTLL12
1
TTLL12 [cytosol]
(R-HSA-8866300)
0.742
7
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.709
9
UniProt:P26641 EEF1G
3
EEF1G [cytosol]
(R-HSA-156925)
EEF1G(1-343)-ALK(1106-1620) fusion [cytosol]
(R-HSA-9710839)
EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol]
(R-HSA-9710850)
0.643
5
UniProt:Q05516 ZBTB16
1
ZBTB16 [cytosol]
(R-HSA-976047)
0.593
4
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.573
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
8
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.564
2
UniProt:Q96IK1-2 Q96IK12
0.556
3
UniProt:O95257 GA45G
0.553
2
UniProt:O43504 LAMTOR5
1
LAMTOR5 [lysosomal membrane]
(R-HSA-5655441)
0.553
2
UniProt:Q9Y6G3 MRPL42
1
MRPL42 [mitochondrial inner membrane]
(R-HSA-5368237)
0.547
2
UniProt:Q16539 MAPK14
7
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.547
3
UniProt:Q9NYA1 SPHK1
4
SPHK1 [nucleoplasm]
(R-HSA-9836616)
p-S225-SPHK1 [nucleoplasm]
(R-HSA-9836613)
p-S225-SPHK1 [cytosol]
(R-HSA-5218716)
SPHK1 [cytosol]
(R-HSA-391267)
0.544
2
UniProt:Q9NZ94-2 NLGN3
0.543
4
UniProt:Q05639 EEF1A2
1
EEF1A2 [cytosol]
(R-HSA-3907261)
0.527
5
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.527
3
UniProt:O75312 ZPR1
0.527
3
UniProt:Q77M19 Q77M19
0.527
2
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.527
2
UniProt:P24534 EEF1B2
1
EEF1B2 [cytosol]
(R-HSA-156926)
0.527
4
UniProt:P43355 MAGA1
0.527
3
UniProt:Q8WVE0 N6AMT2
1
N6AMT2 [cytosol]
(R-HSA-1183209)
0.527
2
UniProt:Q9BVG4 PBDC1
0.527
4
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.527
2
UniProt:P26640 VARS1
1
VARS [cytosol]
(R-HSA-379648)
0.527
4
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.527
3
UniProt:Q8IUH5 ZDH17
0.508
2
UniProt:Q8NFJ9 BBS1
1
BBS1 [cytosol]
(R-HSA-5617640)
0.508
3
UniProt:P03129 VE7
0.488
2
UniProt:P36827 VE7
0.488
2
UniProt:P24837 VE7
0.488
2
UniProt:P06788 VE7
0.488
2
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