Peptide chain elongation

Stable Identifier
Homo sapiens
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The mechanism of a peptide bond requires the movement of three protons. First the deprotonation of the ammonium ion generates a reactive amine, allowing a nucleophilic attack on the carbonyl group. This is followed by the loss of a proton from the reaction intermediate, only to be taken up by the oxygen on the leaving group (from the end of the amino acid chain bound to the tRNA in the P-site). The peptide bond formation results in the net loss of one water molecule, leaving a deacylated-tRNA in the P-site, and a nascent polypeptide chain one amino acid larger in the A-site.
For the purpose of illustration, the figures used in the section show one amino acid being added to a peptidyl-tRNA with a growing peptide chain.

Literature References
PubMed ID Title Journal Year
12297040 The path to perdition is paved with protons

Green, R, Lorsch, JR

Cell 2002
Participant Of
Orthologous Events
Cross References
BioModels Database
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