Reactome | PLK1 phosphorylates NUDC

PLK1 phosphorylates NUDC

Stable Identifier

R-HSA-156682

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Regulation of NUDC by phosphorylation

ReviewStatus

5/5

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The polo-like kinase PLK1 phosphorylates NUDC on serine residues S274 and S326. PLK1-mediated phosphorylation of NUDC is required for both mitotic spindle formation and cytokinesis (Zhou et al. 2003). Interaction of NUDC with dynactin and dynein complexes is also important for its role in mitosis (Aumais et al. 2003). In interphase cells, NUDC is acetylated on lysine residue K39 by an unknown protein acetyl transferase. Deacetylation of NUDC, possibly by HDAC3, at the beginning of mitosis is required for mitotic progression. The interaction of NUDC with PLK1 does not depend on the acetylation status of NUDC (Chuang et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
12679384	Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis Aumais, JP, Williams, SN, Luo, W, Nishino, M, Caldwell, KA, Caldwell, GA, Lin, SH, Yu-Lee, LY	J Cell Sci	2003
12852857	A role for Plk1 phosphorylation of NudC in cytokinesis Zhou, T, Aumais, JP, Liu, X, Yu-Lee, LY, Erikson, RL	Dev Cell	2003