Formation of Exon Junction Complex

Stable Identifier
Homo sapiens
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At the beginning of this reaction, 1 molecule of 'Magoh-Y14 complex', and 1 molecule of 'Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex' are present. At the end of this reaction, 1 molecule of 'Exon Junction Complex' is present.

This reaction takes place in the 'nucleoplasm'.

Literature References
PubMed ID Title Journal Year
23345524 Rearrangements within human spliceosomes captured after exon ligation

Ilagan, JO, Chalkley, RJ, Jurica, MS, Burlingame, AL

RNA 2013
14625303 A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex

Kataoka, N, Dreyfuss, G

J Biol Chem 2004
11118221 The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

Le Hir, H, Moore, MJ, Maquat, LE, Izaurralde, E

EMBO J 2000
12414731 5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly

Moore, MJ, Reichert, VL, Jurica, MS, Le, Hir H

Genes Dev 2002
22959432 CWC22 connects pre-mRNA splicing and exon junction complex assembly

Gehring, NH, Steckelberg, AL, Boehm, V, Gromadzka, AM

Cell Rep 2012
11532962 The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

Le Hir, H, Moore, MJ, Gatfield, D, Izaurralde, E

EMBO J 2001
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