Collagen type IX degradation by MMP3,13

Stable Identifier
R-HSA-1564184
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Collagen type IX degradation by MMP3,13
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Type IX collagen interacts covalently with type II collagen fibril surfaces, suggesting that it represents a macromolecular bridge between fibrils and other cartilage matrix components (Eyre et al. 1987, Olsen 1997). Degradation of type IX (and type II) collagen is seen at the onset of inflammatory arthritis (Kojima et al. 2001).

Collagen type IX is cleaved by MMP3 (Okada et al. 1989, Eyre et al. 1991, Wu et al. 1991) and MMP13 (Knauper et al. 1997).
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Output
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Catalyst Activity

metalloendopeptidase activity of MMP3,13 [extracellular region]

Physical Entity
MMP3,13 [extracellular region] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Inferred From
Collagen type IX degradation (Bos taurus)
Authored
Jupe, S  (2011-07-12)
Reviewed
Sorsa, T  (2012-10-08)
Created
Jupe, S  (2011-09-05)
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