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Collagen type XI degradation by MMP1,2,3,9
Stable Identifier
R-HSA-1564179
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Collagen degradation (Homo sapiens)
Collagen type XI degradation by MMP1,2,3,9 (Homo sapiens)
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Collagen type XI has 3 types of alpha chain. The alpha1(XI) and alpha2(XI) chains are distinct gene products unique to collagen XI, while alpha3(XI) is a hyperglycosylated form of the alpha1 chain for collagen II (Burgeson & Hollister 1979, Morris & Bächinger 1987). Collagen type XI is a fibril-forming collagen found in conjunction with collagens type II and IX in cartilage fibrils (Miller & Gay 1987, Mendler et al. 1989). It is thought to be the structural equivalent of collagen V in connective tissue collagen fibrils. The formation of cartilage collagen fibrils requires collagen XI, suggesting a regulatory function (Li et al. 1995, Wu & Eyre 1995).
Mutations in COL11A1 result in fibrochondrogenesis, a severe, autosomal-recessive, short-limbed skeletal dysplasia (Tompson et al. 2010). Variations in COL11A1, COL11A2 and COL2A1 are associated with the inherited chondrodysplasias Marshall and Stickler syndromes (Annunen et al. 1999).
Collagen type XI is degraded by MMP1 (Eyre et al. 1984), MMP2 (Yu et al. 1990, Smith et al. 1991, Brown et al. 1996), MMP3 (Wu et al. 1991) and MMP9 (Hirose et al. 1992, Pormotabbed et al. 1994).
Participants
Input
Collagen type XI fibril [extracellular region]
(Homo sapiens)
Output
Cleaved collagen type XI fibril [extracellular region]
(Homo sapiens)
Participates
as an event of
Collagen degradation (Homo sapiens)
Catalyst Activity
metalloendopeptidase activity of MMP1,2,3,9 [extracellular region]
Physical Entity
MMP1,2,3,9 [extracellular region]
(Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Inferred From
Collagen type XI degradation by MMP1,2,3,9 (Bos taurus)
Authored
Jupe, S (2011-07-12)
Reviewed
Sorsa, T (2012-10-08)
Created
Jupe, S (2011-09-05)
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