Collagen type IV degradation by MMP2,3,4,9,10,12

Stable Identifier
Reaction [transition]
Homo sapiens
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Type IV collagen is the most abundant structural basement membrane (BM) component, providing a scaffold for other major BM proteins such as laminin (Charonis et al. 1985, 1986). There are six different genes encoding type IV collagen chains, alpha-1 to alpha-6(IV) with distinct tissue distributions. Three alpha chains fold to form the triple helical unit of collagen IV. Three chain combinations have been identified, alpha-1X2 alpha-2(IV), alpha-3,alpha-4, alpha-5(IV) and alpha-5X2, alpha-6(IV) (Borza et al. 2001). The first is the major form, found in all basement membranes, the other types have more restricted distributions.

Collagen IV forms a lattice network rather than extended fibrils. It can be digested by MMP2 (Liotta et al. 1981, Salo et al. 1983, Bergers et al. 2000, Monaco et al. 2006), MMP3 (Okada et al. 1986, Wilhelm et al. 1987, Bejarano et al. 1988, Nicholson et al. 1989), MMP7 (Miyazaki et al. 1990, Murphy et al. 1991), MMP9 (Moll et al. 1990, Morodomi et al. 1992, Murphy et al. 1991, Watanabe et al. 1993, Bergers et al. 2000), MMP10 (Nicholson et al. 1989) and MMP12 (Chandler et al. 1996).

Literature References
PubMed ID Title Journal Year
2169335 Tumor promoter-stimulated Mr 92,000 gelatinase secreted by normal and malignant human cells: isolation and characterization of the enzyme from HT1080 tumor cells

Moll, UM, Youngleib, GL, Rosinski, KB, Quigley, JP

Cancer Res 1990
3223920 Degradation of basement membranes by human matrix metalloproteinase 3 (stromelysin)

Bejarano, PA, Noelken, ME, Suzuki, K, Hudson, BG, Nagase, H

Biochem J 1988
2548603 Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases

Nicholson, R, Murphy, G, Breathnach, R

Biochemistry 1989
17088321 Enzymatic processing of collagen IV by MMP-2 (gelatinase A) affects neutrophil migration and it is modulated by extracatalytic domains

Monaco, S, Sparano, V, Gioia, M, Sbardella, D, Di Pierro, D, Marini, S, Coletta, M

Protein Sci. 2006
6258630 Partial purification and characterization of a neutral protease which cleaves type IV collagen

Liotta, LA, Tryggvason, K, Garbisa, S, Robey, PG, Abe, S

Biochemistry 1981
8920930 Macrophage metalloelastase degrades matrix and myelin proteins and processes a tumour necrosis factor-alpha fusion protein

Chandler, S, Cossins, J, Lury, J, Wells, G

Biochem Biophys Res Commun 1996
2253219 Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line

Miyazaki, K, Hattori, Y, Umenishi, F, Yasumitsu, H, Umeda, M

Cancer Res 1990
Participant Of
Catalyst Activity
Catalyst Activity
metalloendopeptidase activity of MMP2,3,4,9,10,12 [extracellular region]
Physical Entity
Orthologous Events
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