Type VII collagen is the major collagen component of anchoring fibrils, which are essential for the attachment of the epidermis to the dermis. It is degraded by MMP1 (Seltzer et al. 1989), MMP2 (Seltzer et al. 1989, Sawamura et al. 1991, Karelina et al. 2000) and MMP3 (Sawamura et al. 1991). MMP2 is 3000-fold more active than MMP1 (Seltzer et al. 1989).
Eisen, AZ, Burgeson, RE, Bauer, EA, Glanville, RW, Seltzer, JL, Morris, NP
Hashimoto, I, Okada, Y, Bruckner-Tuderman, L, Sawamura, D, Shikata, H, Fujimoto, D, Utsumi, N, Sugawara, T
metalloendopeptidase activity of MMP1,2,3 [extracellular region]
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