Collagen type VII degradation by MMP1,2,3

Stable Identifier
R-HSA-1564120
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Type VII collagen is the major collagen component of anchoring fibrils, which are essential for the attachment of the epidermis to the dermis. It is degraded by MMP1 (Seltzer et al. 1989), MMP2 (Seltzer et al. 1989, Sawamura et al. 1991, Karelina et al. 2000) and MMP3 (Sawamura et al. 1991). MMP2 is 3000-fold more active than MMP1 (Seltzer et al. 1989).

Literature References
PubMed ID Title Journal Year
1704217 Increased gene expression of matrix metalloproteinase-3 (stromelysin) in skin fibroblasts from patients with severe recessive dystrophic epidermolysis bullosa

Sawamura, D, Sugawara, T, Hashimoto, I, Bruckner-Tuderman, L, Fujimoto, D, Okada, Y, Utsumi, N, Shikata, H

Biochem Biophys Res Commun 1991
2537292 Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin

Seltzer, JL, Eisen, AZ, Bauer, EA, Morris, NP, Glanville, RW, Burgeson, RE

J Biol Chem 1989
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of MMP1,2,3 [extracellular region]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created