Collagen type VII degradation by MMP1,2,3

Stable Identifier
R-HSA-1564120
Type
Reaction
Species
Homo sapiens
Compartment
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Type VII collagen is the major collagen component of anchoring fibrils, which are essential for the attachment of the epidermis to the dermis. It is degraded by MMP1 (Seltzer et al. 1989), MMP2 (Seltzer et al. 1989, Sawamura et al. 1991, Karelina et al. 2000) and MMP3 (Sawamura et al. 1991). MMP2 is 3000-fold more active than MMP1 (Seltzer et al. 1989).

Literature References
PubMed ID Title Journal Year
2537292 Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin

Eisen, AZ, Burgeson, RE, Bauer, EA, Glanville, RW, Seltzer, JL, Morris, NP

J Biol Chem 1989
1704217 Increased gene expression of matrix metalloproteinase-3 (stromelysin) in skin fibroblasts from patients with severe recessive dystrophic epidermolysis bullosa

Hashimoto, I, Okada, Y, Bruckner-Tuderman, L, Sawamura, D, Shikata, H, Fujimoto, D, Utsumi, N, Sugawara, T

Biochem Biophys Res Commun 1991
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Catalyst Activity

metalloendopeptidase activity of MMP1,2,3 [extracellular region]

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