Reactome | Collagen type VII degradation by MMP1,2,3

Collagen type VII degradation by MMP1,2,3

Stable Identifier

R-HSA-1564120

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Collagen type VII degradation by MMP1,2,3

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Type VII collagen is the major collagen component of anchoring fibrils, which are essential for the attachment of the epidermis to the dermis. It is degraded by MMP1 (Seltzer et al. 1989), MMP2 (Seltzer et al. 1989, Sawamura et al. 1991, Karelina et al. 2000) and MMP3 (Sawamura et al. 1991). MMP2 is 3000-fold more active than MMP1 (Seltzer et al. 1989).

Literature References

PubMed ID	Title	Journal	Year
2537292	Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin Seltzer, JL, Eisen, AZ, Bauer, EA, Morris, NP, Glanville, RW, Burgeson, RE	J Biol Chem	1989
1704217	Increased gene expression of matrix metalloproteinase-3 (stromelysin) in skin fibroblasts from patients with severe recessive dystrophic epidermolysis bullosa Sawamura, D, Sugawara, T, Hashimoto, I, Bruckner-Tuderman, L, Fujimoto, D, Okada, Y, Utsumi, N, Shikata, H	Biochem Biophys Res Commun	1991