Indirect recruitment of PI3K to KIT via p(Y)-GAB2

Stable Identifier
R-HSA-1562641
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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Indirect recruitment of PI3K to KIT via p(Y)-GAB2
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Phosphorylated GAB2 recruits the p85 subunit of the PI3K complex and activates the PI3K/AKT pathway. This is one of two mechanisms described for the recruitment of PI3K to KIT.

Literature References
PubMed ID Title Journal Year
18697750 Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit

Sun, J, Pedersen, M, Rönnstrand, L

J Biol Chem 2008
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Orthologous Events
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Bos taurus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Danio rerio)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Gallus gallus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Mus musculus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Rattus norvegicus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Sus scrofa)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Xenopus tropicalis)
Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2011-09-05)
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