Indirect recruitment of PI3K to KIT via p(Y)-GAB2

Stable Identifier
R-HSA-1562641
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Indirect recruitment of PI3K to KIT via p(Y)-GAB2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phosphorylated GAB2 recruits the p85 subunit of the PI3K complex and activates the PI3K/AKT pathway. This is one of two mechanisms described for the recruitment of PI3K to KIT.
Literature References
PubMed ID Title Journal Year
18697750 Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit

Sun, J, Pedersen, M, Rönnstrand, L

J Biol Chem 2008
Participants
Input
Output
Participates
as an event of
Orthologous Events
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Bos taurus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Gallus gallus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Mus musculus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Rattus norvegicus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Sus scrofa)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Xenopus tropicalis)
Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2011-09-05)
Cite Us!