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Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements
Stable Identifier
R-HSA-1535903
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
Signaling by NODAL (Homo sapiens)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Homo sapiens)
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FOXO3 (FOXO3A) interacts with phospho-SMAD2 and phospho-SMAD3 complexed with CO-SMAD (SMAD4) at a promoter containing the FoxO3a-binding Element (Fu and Peng 20110).
Literature References
PubMed ID
Title
Journal
Year
21532621
Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells
Peng, C
,
Fu, G
Oncogene
2011
Participants
Input
FOXO3 [nucleoplasm]
(Homo sapiens)
FoxO3a-binding Element [nucleoplasm]
p-2S-SMAD2,3:SMAD4 [nucleoplasm]
(Homo sapiens)
Output
SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Signaling by NODAL (Homo sapiens)
Orthologous Events
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Bos taurus)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Caenorhabditis elegans)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Canis familiaris)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Drosophila melanogaster)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Mus musculus)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Rattus norvegicus)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Sus scrofa)
Authored
May, B (2011-08-26)
Reviewed
Peng, C (2011-08-25)
Created
May, B (2011-08-26)
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