Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PLA2G4A [mitochondrial inner membrane]
Stable Identifier
R-HSA-1524099
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
cPLA2, Cytosolic phospholipase A2, PA24A_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
Acyl chain remodeling of CL (Homo sapiens)
MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Homo sapiens)
PLA2G4A:Ca2+ [mitochondrial inner membrane] (Homo sapiens)
PLA2G4A [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P47712 PLA2G4A
Gene Names
PLA2G4A, CPLA2, PLA2G4
Chain
chain:1-749
Reference Genes
BioGPS Gene:5321 PLA2G4A
COSMIC (genes):PLA2G4A PLA2G4A
CTD Gene:5321 PLA2G4A
dbSNP Gene:5321 PLA2G4A
ENSEMBL:ENSG00000116711 PLA2G4A
HGNC:9035 PLA2G4A
KEGG:hsa:5321 PLA2G4A
Monarch:5321 PLA2G4A
NCBI Gene:5321 PLA2G4A
OMIM:600522 PLA2G4A
UCSC:P47712 PLA2G4A
Reference Transcript
RefSeq:NM_001311193.1 PLA2G4A
RefSeq:NM_024420.2 PLA2G4A
RefSeq:XM_011509642.2 PLA2G4A
Other Identifiers
11727754_a_at
16675197
210145_PM_at
210145_at
2372212
2372219
2372220
2372222
2372224
2372225
2372226
2372227
2372231
2372234
2372235
2372236
2372237
2372240
2372242
2372243
2372245
2372246
2372248
2372249
2372251
35938_at
5321
7908351
A_14_P107053
A_14_P112455
A_14_P121124
A_14_P134547
A_23_P11685
GE62936
GO:0000139
GO:0001516
GO:0002827
GO:0003824
GO:0004620
GO:0004622
GO:0004623
GO:0005509
GO:0005544
GO:0005634
GO:0005635
GO:0005737
GO:0005743
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0005975
GO:0006071
GO:0006629
GO:0006640
GO:0006650
GO:0006663
GO:0006690
GO:0008289
GO:0008374
GO:0009395
GO:0010314
GO:0010572
GO:0016020
GO:0016740
GO:0016787
GO:0019369
GO:0019370
GO:0032266
GO:0032308
GO:0034478
GO:0034638
GO:0036151
GO:0042127
GO:0043032
GO:0043226
GO:0043231
GO:0046456
GO:0046475
GO:0046872
GO:0047498
GO:0047499
GO:0050482
GO:0051649
GO:0052689
GO:0070273
GO:0071236
GO:1902387
HMNXSV003024546
ILMN_1803561
M68874_at
PH_hs_0012271
TC01001607.hg
g190003_3p_at
Participates
as a component of
PLA2G4A:Ca2+ [mitochondrial inner membrane] (Homo sapiens)
Other forms of this molecule
PLA2G4A [endoplasmic reticulum membrane]
p-S505,S727-PLA2G4A [endoplasmic reticulum membrane]
PLA2G4A [cytosol]
Inferred To
PLB3 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
PLB1 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
PLB2 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
Homologues of PLA2G4A [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
Homologues of PLA2G4A [mitochondrial inner membrane]
(Schizosaccharomyces pombe)
plb1 [mitochondrial inner membrane]
(Schizosaccharomyces pombe)
PLA2G4A [mitochondrial inner membrane]
(Bos taurus)
PLA2G4A [mitochondrial inner membrane]
(Canis familiaris)
PLA2G4A [mitochondrial inner membrane]
(Danio rerio)
PLA2G4A [mitochondrial inner membrane]
(Gallus gallus)
PLA2G4A [mitochondrial inner membrane]
(Mus musculus)
PLA2G4A [mitochondrial inner membrane]
(Rattus norvegicus)
PLA2G4A [mitochondrial inner membrane]
(Schizosaccharomyces pombe)
PLA2G4A [mitochondrial inner membrane]
(Sus scrofa)
PLA2G4A [mitochondrial inner membrane]
(Xenopus tropicalis)
SPO1 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_077734.1
,
NP_001298122.1
,
XP_011507944.1
Guide to Pharmacology - Targets
1424
ENSEMBL
ENST00000367466
,
ENSP00000356436
OpenTargets
ENSG00000116711
ZINC - Substances
PA24A_HUMAN
ZINC target
P47712
PRO
P47712
PDB
1BCI
,
1CJY
,
1RLW
IntEnz
3.1.1.5
HPA
ENSG00000116711-PLA2G4A
Pharos - Targets
P47712
Orphanet
PLA2G4A
ZINC - Predictions - Purchasable
PA24A_HUMAN
HMDB Protein
HMDBP00060
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text