DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex

Stable Identifier
R-HSA-1504213
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In response to WNT signaling, DVL is recruited to the CUL3:KLHL12:RBX1 ubiquitin ligase complex and is subsequently polyubiquitinated and degraded. The BTB domains of the adaptor protein KLHL12 bind constitutively to CUL3 while its Kelch domains mediate a WNT-dependent interaction with the C-terminus of DVL (Angers et al, 2006).

Literature References
PubMed ID Title Journal Year
16547521 The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation

Angers, S, Thorpe, CJ, Biechele, TL, Goldenberg, SJ, Zheng, N, Maccoss, MJ, Moon, RT

Nat Cell Biol 2006
Participants
Participant Of
Orthologous Events
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Created