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WNT:FZD:LRP5/6:DVL [plasma membrane]
Stable Identifier
R-HSA-1504192
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Beta-catenin is released from the destruction complex (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
FZD recruits DVL to the receptor complex (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
Participants
components
pp-DVL [cytosol]
(Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane]
(Homo sapiens)
Participates
as an output of
FZD recruits DVL to the receptor complex (Homo sapiens)
as an input of
DVL recruits GSK3beta:AXIN1 to the receptor complex (Homo sapiens)
as a component of
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
Inferred To
WNT:FZD:LRP5/6:DVL [plasma membrane]
(Bos taurus)
WNT:FZD:LRP5/6:DVL [plasma membrane]
(Caenorhabditis elegans)
WNT:FZD:LRP5/6:DVL [plasma membrane]
(Canis familiaris)
WNT:FZD:LRP5/6:DVL [plasma membrane]
(Danio rerio)
WNT:FZD:LRP5/6:DVL [plasma membrane]
(Drosophila melanogaster)
WNT:FZD:LRP5/6:DVL [plasma membrane]
(Gallus gallus)
WNT:FZD:LRP5/6:DVL [plasma membrane]
(Mus musculus)
WNT:FZD:LRP5/6:DVL [plasma membrane]
(Rattus norvegicus)
WNT:FZD:LRP5/6:DVL [plasma membrane]
(Sus scrofa)
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