Peroxynitrite is reduced by AhpE

Stable Identifier
R-HSA-1500804
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
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Peroxynitrite is reduced by AhpE
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The peroxiredoxin AhpE participates in reducing peroxynitrite to nitrite, but how it is recycled back to the reduced form is still unknown (Hugo et al. 2009).

Literature References
PubMed ID Title Journal Year
19737009 Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics

Hugo, M, Turell, L, Manta, B, Botti, H, Monteiro, G, Netto, LE, Alvarez, B, Radi, R, Trujillo, M

Biochemistry 2009
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
peroxiredoxin activity of AhpE dimer (red.) [cytosol]
Physical Entity
AhpE dimer (red.) [cytosol]
Activity
peroxiredoxin activity (0051920)
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
Target Pathogen
Authored
Schmidt, EE  (2006-02-06)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-08-22)
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