Reactome | Fgd1 reactivates F420

Fgd1 reactivates F420

Stable Identifier

R-HSA-1500781

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Mycobacterium tuberculosis

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Infection with Mycobacterium tuberculosis (Homo sapiens)
      - Latent infection - Other responses of Mtb to phagocytosis (Homo sapiens)
        
        Cell redox homeostasis (Homo sapiens)
        
        Fgd1 reactivates F420 (Homo sapiens)

General

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The enzyme in Mtb known to reduce F420 is the glucose-6-phosphate dehydrogenase Fgd1 (Bashiri et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18434308	Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding Squire, CJ, Moreland, NJ, Bashiri, G, Baker, EN	J Biol Chem	2008

Participants

Input

Output

Participates

as an event of

Cell redox homeostasis (Homo sapiens)

Catalyst Activity

oxidoreductase activity, acting on CH-OH group of donors of Fgd1 [cytosol]

Physical Entity

Fgd1 [cytosol] (Mycobacterium tuberculosis)

Activity

oxidoreductase activity, acting on CH-OH group of donors (GO:0016614)

Disease

Name	Identifier	Synonyms
tuberculosis	DOID:399	tuberculous abscess, Tuberculoma (finding), tuberculoma

Authored

Stephan, R (2011-01-10)

Reviewed

Warner, D (2012-04-30)

Created

Jassal, B (2011-08-22)

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