Reactome | Fgd1 reactivates F420

Fgd1 reactivates F420

Stable Identifier

R-HSA-1500781

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Mycobacterium tuberculosis

Compartment

cytosol

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The enzyme in Mtb known to reduce F420 is the glucose-6-phosphate dehydrogenase Fgd1 (Bashiri et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18434308	Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding Bashiri, G, Squire, CJ, Moreland, NJ, Baker, EN	J Biol Chem	2008

Participants

Input

Output

Participant Of

hasEvent

Cell redox homeostasis

Catalyst Activity

Title

oxidoreductase activity, acting on CH-OH group of donors of Fgd1 [cytosol]

Physical Entity

Fgd1 [cytosol]

Activity

oxidoreductase activity, acting on CH-OH group of donors (0016614)

Disease

Name	Identifier	Synonyms
tuberculosis	399	tuberculous abscess, Tuberculoma (finding), tuberculoma

Authored

Stephan, R (2011-01-10)

Reviewed

Warner, D (2012-04-30)

Created

Jassal, B (2011-08-22)