Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-)

Stable Identifier
R-HSA-1497878
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-)
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Superoxide (O2.-) formed from an uncoupled eNOS action, together with nitric oxide (NO) formed from a coupled eNOS action, readily react together to fom peroxynitrite (ONOO-) (Jourd'heuil et al. 2001, Reiter et al. 2000).

Literature References
PubMed ID Title Journal Year
11373284 Reaction of superoxide and nitric oxide with peroxynitrite. Implications for peroxynitrite-mediated oxidation reactions in vivo

Jourd'heuil, D, Jourd'heuil, FL, Kutchukian, PS, Musah, RA, Wink, DA, Grisham, MB

J Biol Chem 2001
10906340 Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite

Reiter, CD, Teng, RJ, Beckman, JS

J Biol Chem 2000
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Cross References
Rhea
Authored
Jassal, B  (2011-08-17)
Reviewed
D'Eustachio, P  (2011-08-23)
Created
Jassal, B  (2011-08-17)
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