Reactome | Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II

Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II

Stable Identifier

R-HSA-1497853

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II

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To become active, sepiapterin reductase (SPR) must first be phosphorylated (serine 213 in humans) by Ca2+/calmodulin-dependent protein kinase II (Fujimoto et al. 2002, Katoh et al. 1994).

Literature References

PubMed ID	Title	Journal	Year
8137944	Phosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein kinase C of sepiapterin reductase, the terminal enzyme in the biosynthetic pathway of tetrahydrobiopterin Yamamoto, Y, Katoh, S, Takahashi, SY, Sueoka, T	FEBS Lett	1994
11825621	Mutational analysis of sites in sepiapterin reductase phosphorylated by Ca2+/calmodulin-dependent protein kinase II Katoh, S, Takahashi, SY, Fujimoto, K	Biochim Biophys Acta	2002