To become active, sepiapterin reductase (SPR) must first be phosphorylated (serine 213 in humans) by Ca2+/calmodulin-dependent protein kinase II (Fujimoto et al. 2002, Katoh et al. 1994).
Katoh, S, Takahashi, SY, Fujimoto, K
Yamamoto, Y, Katoh, S, Takahashi, SY, Sueoka, T
cGMP-dependent protein kinase activity of PRKG2 [cytosol]
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