To become active, sepiapterin reductase (SPR) must first be phosphorylated (serine 213 in humans) by Ca2+/calmodulin-dependent protein kinase II (Fujimoto et al. 2002, Katoh et al. 1994).
Katoh, S, Sueoka, T, Yamamoto, Y, Takahashi, SY
Fujimoto, K, Takahashi, SY, Katoh, S
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