Reactome | Uncoupled eNOS favours the formation of superoxide

Uncoupled eNOS favours the formation of superoxide

Stable Identifier

R-HSA-1497810

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Uncoupled eNOS favours the formation of superoxide

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BH2 may compete with BH4 to bind eNOS, uncoupling eNOS leading to the formation of superoxide rather than nitric oxide. BH2, the oxidised form of BH4, cannot contribute electrons to heme in the reductase domain of eNOS, thereby uncoupling it from arginine oxidation and producing superoxide from oxygen instead (Vasquez-Vivar et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11879202	The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study Vásquez-Vivar, J, Martasek, P, Whitsett, J, Joseph, J, Kalyanaraman, B	Biochem J	2002