Reactome | ETA is phosphorylated to PETA by CHK/ETNK

ETA is phosphorylated to PETA by CHK/ETNK

Stable Identifier

R-HSA-1483222

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ETA is phosphorylated to PETA by CHK/ETNK

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In the cytosol, ethanolamine (ETA) is phosphorylated to phosphoethanolamine (PETA) by choline kinase (CHK) dimer or by ethanolamine kinase 1/2 (ETNK1/2) (Lykidis et al. 2001, Gallego-Ortega et al. 2009). CHK dimer consists of either choline kinase alpha subunit (CHKA) or beta subunit (CHKB) homodimer, or of CHKA:CHKB heterodimer.

Literature References

PubMed ID	Title	Journal	Year
11044454	Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway Wang, J, Jackowski, S, Karim, MA, Lykidis, A	J Biol Chem	2001
19915674	Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment Ramirez de Molina, A, Lacal, JC, Barderas, MG, Valdes-Mora, F, Ramos, MA, Sarmentero-Estrada, J, Gallego-Ortega, D	PLoS One	2009