Reactome | ETA is phosphorylated to PETA by CHK/ETNK

ETA is phosphorylated to PETA by CHK/ETNK

Stable Identifier

R-HSA-1483222

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

ETA is phosphorylated to PETA by CHK/ETNK

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In the cytosol, ethanolamine (ETA) is phosphorylated to phosphoethanolamine (PETA) by choline kinase (CHK) dimer or by ethanolamine kinase 1/2 (ETNK1/2) (Lykidis et al. 2001, Gallego-Ortega et al. 2009). CHK dimer consists of either choline kinase alpha subunit (CHKA) or beta subunit (CHKB) homodimer, or of CHKA:CHKB heterodimer.

Literature References

PubMed ID	Title	Journal	Year
19915674	Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment Gallego-Ortega, D, Ramirez de Molina, A, Ramos, MA, Valdes-Mora, F, Barderas, MG, Sarmentero-Estrada, J, Lacal, JC	PLoS One	2009
11044454	Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway Lykidis, A, Wang, J, Karim, MA, Jackowski, S	J Biol Chem	2001