ETA is phosphorylated to PETA by CHK/ETNK

Stable Identifier
R-HSA-1483222
Type
Reaction
Species
Homo sapiens
Compartment
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In the cytosol, ethanolamine (ETA) is phosphorylated to phosphoethanolamine (PETA) by choline kinase (CHK) dimer or by ethanolamine kinase 1/2 (ETNK1/2) (Lykidis et al. 2001, Gallego-Ortega et al. 2009). CHK dimer consists of either choline kinase alpha subunit (CHKA) or beta subunit (CHKB) homodimer, or of CHKA:CHKB heterodimer.

Literature References
PubMed ID Title Journal Year
11044454 Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway

Wang, J, Jackowski, S, Karim, MA, Lykidis, A

J Biol Chem 2001
19915674 Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment

Ramirez de Molina, A, Lacal, JC, Barderas, MG, Valdes-Mora, F, Ramos, MA, Sarmentero-Estrada, J, Gallego-Ortega, D

PLoS One 2009
Participants
Participates
Catalyst Activity

ethanolamine kinase activity of CHK/ETNK [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Created
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