PG transports from the ER membrane to the late endosome membrane

Stable Identifier
R-HSA-1483218
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Lysobisphosphatidic acid, also known as bis(monoacylglycerol) hydrogen phosphate (BMP), is enriched in late endosomes and not found in the endoplasmic reticulum (ER) or mitochondria where phosphatidylglycerol (PG) is synthesised. Late endosomes form membrane contact sites with the ER, providing a means for PG to enter the late endosome and be converted to BMP (Levine 2004, Eden et al. 2010, Kobayashi et al. 1998, Hullin-Matsuda et al. 2007, Kobayashi et al. 1999).

Literature References
PubMed ID Title Journal Year
20118922 Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interaction

Eden, ER, White, IJ, Tsapara, A, Futter, CE

Nat Cell Biol 2010
15350976 Short-range intracellular trafficking of small molecules across endoplasmic reticulum junctions

Levine, T

Trends Cell Biol 2004
17558022 De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate

Hullin-Matsuda, F, Kawasaki, K, Delton-Vandenbroucke, I, Xu, Y, Nishijima, M, Lagarde, M, Schlame, M, Kobayashi, T

J Lipid Res 2007
10559883 Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport

Kobayashi, T, Beuchat, MH, Lindsay, M, Frias, S, Palmiter, RD, Sakuraba, H, Parton, RG, Gruenberg, J

Nat Cell Biol 1999
9515966 A lipid associated with the antiphospholipid syndrome regulates endosome structure and function

Kobayashi, T, Stang, E, Fang, KS, de Moerloose, P, Parton, RG, Gruenberg, J

Nature 1998
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