Synthesis of PE

Stable Identifier
R-HSA-1483213
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Synthesis of PE
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De novo (Kennedy pathway) synthesis of phosphatidylethanolamine (PE) involves phosphorylation of ethanolamine (ETA) to phosphoethanolamine (PETA) followed by condensing with cytidine triphosphate (CTP) to form CDP-ethanolamine (CDP-ETA). Diacylglycerol (DAG) and CDP-ETA together then form PE. Alternatively, PE is formed when phosphatidylserine (PS) is decarboxylated by phosphatidylserine decarboxylase proenzyme (PISD) (Henneberry et al. 2002, Vance 1991, Vance 1990).

Literature References
Participants
Events
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as an event of
Event Information
Go Biological Process
phosphatidylethanolamine biosynthetic process (0006646)
Orthologous Events
Synthesis of PE (Bos taurus)
Synthesis of PE (Caenorhabditis elegans)
Synthesis of PE (Canis familiaris)
Synthesis of PE (Danio rerio)
Synthesis of PE (Dictyostelium discoideum)
Synthesis of PE (Drosophila melanogaster)
Synthesis of PE (Gallus gallus)
Synthesis of PE (Mus musculus)
Synthesis of PE (Plasmodium falciparum)
Synthesis of PE (Rattus norvegicus)
Synthesis of PE (Saccharomyces cerevisiae)
Synthesis of PE (Schizosaccharomyces pombe)
Synthesis of PE (Sus scrofa)
Synthesis of PE (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-08-12)
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