PS is decarboxylated to PE by PISD

Stable Identifier
R-HSA-1483212
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane, mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PS is decarboxylated to PE by PISD
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the inner mitochondrial (IM) membrane, phosphatidylserine decarboxylase proenzyme (heterodimer of two chains from the same protein) (PISD) decarboxylates phosphatidylserine (PS) to phosphatidylethanolamine (PE). This event has been inferred from rats and limited data for a human PISD (Forbes et al. 2007).

Literature References
PubMed ID Title Journal Year
17478478 High-throughput mass spectrometry screening for inhibitors of phosphatidylserine decarboxylase

Lumb, KJ, Pendleton, JA, Rocks, S, Forbes, CD, Landro, JA, Gedrich, RW, Ozbal, CC, Osterman, DG, Lamarr, WA, Toth, JG

J Biomol Screen 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatidylserine decarboxylase activity of PISD:Pyruvoyl [mitochondrial inner membrane]

Physical Entity
PISD:Pyruvoyl [mitochondrial inner membrane] (Homo sapiens)
Activity
phosphatidylserine decarboxylase activity (GO:0004609)
Inferred From
PS is decarboxylated to PE by Pisd (Rattus norvegicus)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
Cite Us!