PG is converted to BMP

Stable Identifier
R-HSA-1483209
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The biosynthetic pathway of lysobisphosphatidic acid, also known as bis(monoacylglycerol) hydrogen phosphate (BMP), is still not fully understood with the in vivo enzymes responsible yet to be fully identified. It appears to involve multiple steps including hydrolysis of phosphatidylglycerol (PG) by a phospholipase A2, acylation, and a reorientation of the phosphoryl ester (Poorthuis & Hostetler 1978, Heravi & Waite 1999, Hullin-Matsuda et al. 2007, Gallala & Sandhoff 2010).

Literature References
PubMed ID Title Journal Year
10101262 Transacylase formation of bis(monoacylglycerol)phosphate

Heravi, J, Waite, M

Biochim Biophys Acta 1999
21136156 Biological Function of the Cellular Lipid BMP-BMP as a Key Activator for Cholesterol Sorting and Membrane Digestion

Gallala, HD, Sandhoff, K

Neurochem Res 2010
650089 Conversion of diphosphatidylglycerol to bis(monoacylglyceryl)phosphate by lysosomes

Poorthuis, BJ, Hostetler, KY

J Lipid Res 1978
17558022 De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate

Hullin-Matsuda, F, Kawasaki, K, Delton-Vandenbroucke, I, Xu, Y, Nishijima, M, Lagarde, M, Schlame, M, Kobayashi, T

J Lipid Res 2007
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