PC is hydrolyzed to PA and choline by PLD1/2

Stable Identifier
R-HSA-1483182
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphatidylcholine (PC) is hydrolyzed to phosphatidic acid (PA) and choline (Cho) by the enzymes phospholipase D1/2 (PLD1/2), at the endoplasmic reticulum (ER) membrane (Lopez et al. 1998, Hammond et al. 1995).

Literature References
PubMed ID Title Journal Year
9582313 Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2

Lopez, I, Arnold, RS, Lambeth, JD

J Biol Chem 1998
8530346 Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family

Hammond, SM, Altshuller, YM, Sung, TC, Rudge, SA, Rose, K, Engebrecht, J, Morris, AJ, Frohman, MA

J Biol Chem 1995
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phospholipase D activity of PLD1/2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created