Reactome | PC is hydrolyzed to PA and choline by PLD1/2

PC is hydrolyzed to PA and choline by PLD1/2

Stable Identifier

R-HSA-1483182

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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PC is hydrolyzed to PA and choline by PLD1/2

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Phosphatidylcholine (PC) is hydrolyzed to phosphatidic acid (PA) and choline (Cho) by the enzymes phospholipase D1/2 (PLD1/2), at the endoplasmic reticulum (ER) membrane (Lopez et al. 1998, Hammond et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
8530346	Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family Altshuller, YM, Hammond, SM, Frohman, MA, Morris, AJ, Engebrecht, J, Rose, K, Sung, TC, Rudge, SA	J Biol Chem	1995
9582313	Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2 Lambeth, JD, Arnold, RS, Lopez, I	J Biol Chem	1998