PC is hydrolyzed to PA and choline by PLD1/2

Stable Identifier
R-HSA-1483182
Type
Reaction
Species
Homo sapiens
Compartment
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Phosphatidylcholine (PC) is hydrolyzed to phosphatidic acid (PA) and choline (Cho) by the enzymes phospholipase D1/2 (PLD1/2), at the endoplasmic reticulum (ER) membrane (Lopez et al. 1998, Hammond et al. 1995).

Literature References
PubMed ID Title Journal Year
8530346 Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family

Altshuller, YM, Hammond, SM, Frohman, MA, Morris, AJ, Engebrecht, J, Rose, K, Sung, TC, Rudge, SA

J Biol Chem 1995
9582313 Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2

Lambeth, JD, Arnold, RS, Lopez, I

J Biol Chem 1998
Participants
Participates
Catalyst Activity

phospholipase D activity of PLD1/2 [endoplasmic reticulum membrane]

Orthologous Events
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