PE is methylated to PC by PEMT

Stable Identifier
R-HSA-1483174
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine N-methyltransferase (PEMT) methylates phosphatidylethanolamine (PE) and produces phosphatidylcholine (PC) (Vance & Ridgway 1998, Shields et al. 2001, Guan et al. 1999).

Literature References
PubMed ID Title Journal Year
11420179 Structure, expression profile and alternative processing of the human phosphatidylethanolamine N-methyltransferase (PEMT) gene

Shields, DJ, Agellon, LB, Vance, DE

Biochim Biophys Acta 2001
10100195 Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease

Guan, ZZ, Wang, YN, Xiao, KQ, Hu, PS, Liu, JL

Neurochem Int 1999
3057511 The methylation of phosphatidylethanolamine

Vance, DE, Ridgway, ND

Prog Lipid Res 1988
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phosphatidylethanolamine N-methyltransferase activity of PEMT [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created
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