Synthesis of BMP

Stable Identifier
R-HSA-1483171
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Pathway
Species
Homo sapiens
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Lysobisphosphatidic acid, also known as bis(monoacylglycerol) hydrogen phosphate (BMP), is enriched in late endosomes and not found in the endoplasmic reticulum (ER) or mitochondria where phosphatidylglycerol (PG) is synthesized. Late endosomes form membrane contact sites with the ER, providing a means for PG to enter the late endosome and be converted to BMP via hydrolysis by a phospholipase A2, followed by acylation, and a reorientation of the phosphoryl ester (Poorthuis & Hostetler 1978, Heravi & Waite 1999, Hullin-Matsuda et al. 2007, Gallala & Sandhoff 2010).

Literature References
PubMed ID Title Journal Year
10101262 Transacylase formation of bis(monoacylglycerol)phosphate

Heravi, J, Waite, M

Biochim Biophys Acta 1999
21136156 Biological Function of the Cellular Lipid BMP-BMP as a Key Activator for Cholesterol Sorting and Membrane Digestion

Gallala, HD, Sandhoff, K

Neurochem Res 2010
650089 Conversion of diphosphatidylglycerol to bis(monoacylglyceryl)phosphate by lysosomes

Poorthuis, BJ, Hostetler, KY

J Lipid Res 1978
17558022 De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate

Hullin-Matsuda, F, Kawasaki, K, Delton-Vandenbroucke, I, Xu, Y, Nishijima, M, Lagarde, M, Schlame, M, Kobayashi, T

J Lipid Res 2007
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