Reactome | PA is converted to CDP-DAG by CDS2

PA is converted to CDP-DAG by CDS2

Stable Identifier

R-HSA-1483165

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial matrix

ReviewStatus

5/5

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At the inner mitochondrial (IM) membrane, phosphatidate cytidylyltransferase 2 (CDS2) converts phosphatidic acid (PA) and cytidine triphosphate (CTP) into cytidine diphosphate-diacylglycerol (CDP-DAG). Both ER and mitochondrial membranes have the capability to synthesise cytidine diphosphate-diacylglycerol (CDP-DAG) with phosphatidate cytidylyltransferase 1 and 2 (CDS1 and CDS2) (Lykidis et al. 1997, Schlame & Haldar 1993). However, transport of CDP-DAG between organelles cannot be ruled out (Stuhne-Sekalec et al. 1986).

Literature References

PubMed ID	Title	Journal	Year
8380172	Cardiolipin is synthesized on the matrix side of the inner membrane in rat liver mitochondria Haldar, D, Schlame, M	J Biol Chem	1993
9407135	The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content Rock, CO, Jackson, PD, Jackowski, S, Lykidis, A	J Biol Chem	1997
3718705	Participation of the microsomal CDP-diglycerides in the mitochondrial biosynthesis of phosphatidylglycerol Stanacev, NZ, Stuhne-Sekalec, L, Chudzik, J	Biochem Cell Biol	1986