At the inner mitochondrial (IM) membrane, phosphatidate cytidylyltransferase 2 (CDS2) converts phosphatidic acid (PA) and cytidine triphosphate (CTP) into cytidine diphosphate-diacylglycerol (CDP-DAG). Both ER and mitochondrial membranes have the capability to synthesise cytidine diphosphate-diacylglycerol (CDP-DAG) with phosphatidate cytidylyltransferase 1 and 2 (CDS1 and CDS2) (Lykidis et al. 1997, Schlame & Haldar 1993). However, transport of CDP-DAG between organelles cannot be ruled out (Stuhne-Sekalec et al. 1986).
Haldar, D, Schlame, M
Rock, CO, Jackson, PD, Jackowski, S, Lykidis, A
Stanacev, NZ, Stuhne-Sekalec, L, Chudzik, J
phosphatidate cytidylyltransferase activity of CDS2 [mitochondrial inner membrane]
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