PC is transphosphatidylated to PG by PLD1-4/6

Stable Identifier
R-HSA-1483142
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the endoplasmic reticulum (ER) membrane, phospholipase D1-4,6 (PLD1-4,6) transphosphatidylates phosphatidylcholine (PC) with glycerol to displace choline (Cho) and form phosphatidylglycerol (PG). This reaction is inferred from rats, but PLD enzymes are present in humans (Hammond et al. 1995, Steed et al. 1998, Cao et al. 1997).

Literature References
PubMed ID Title Journal Year
9140189 A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily

Cao, JX, Koop, BF, Upton, C

Virus Res 1997
8530346 Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family

Hammond, SM, Altshuller, YM, Sung, TC, Rudge, SA, Rose, K, Engebrecht, J, Morris, AJ, Frohman, MA

J Biol Chem 1995
9761774 Characterization of human PLD2 and the analysis of PLD isoform splice variants

Steed, PM, Clark, KL, Boyar, WC, Lasala, DJ

FASEB J 1998
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phospholipase D activity of PLD1-4/6 [endoplasmic reticulum membrane]
Physical Entity
Activity
Inferred From
Authored
Created
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