PC is transphosphatidylated to PG by PLD1-4/6

Stable Identifier
R-HSA-1483142
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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PC is transphosphatidylated to PG by PLD1-4/6
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In the endoplasmic reticulum (ER) membrane, phospholipase D1-4,6 (PLD1-4,6) transphosphatidylates phosphatidylcholine (PC) with glycerol to displace choline (Cho) and form phosphatidylglycerol (PG). This reaction is inferred from rats, but PLD enzymes are present in humans (Hammond et al. 1995, Steed et al. 1998, Cao et al. 1997).
Literature References
PubMed ID Title Journal Year
8530346 Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family

Hammond, SM, Altshuller, YM, Sung, TC, Rudge, SA, Rose, K, Engebrecht, J, Morris, AJ, Frohman, MA

J Biol Chem 1995
9140189 A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily

Cao, JX, Koop, BF, Upton, C

Virus Res 1997
9761774 Characterization of human PLD2 and the analysis of PLD isoform splice variants

Steed, PM, Clark, KL, Boyar, WC, Lasala, DJ

FASEB J 1998
Participants
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Output
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Catalyst Activity

D-type glycerophospholipase activity of PLD1-4/6 [endoplasmic reticulum membrane]

Physical Entity
PLD1-4/6 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
D-type glycerophospholipase activity (GO:0004630)
Inferred From
PC is transphosphatidylated to PG by Pld1-4/6 (Mus musculus)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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