PC is transphosphatidylated to PG by PLD1-4/6

Stable Identifier
Reaction [transition]
Homo sapiens
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In the endoplasmic reticulum (ER) membrane, phospholipase D1-4,6 (PLD1-4,6) transphosphatidylates phosphatidylcholine (PC) with glycerol to displace choline (Cho) and form phosphatidylglycerol (PG). This reaction is inferred from rats, but PLD enzymes are present in humans (Hammond et al. 1995, Steed et al. 1998, Cao et al. 1997).

Literature References
PubMed ID Title Journal Year
8530346 Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family

Altshuller, YM, Hammond, SM, Frohman, MA, Morris, AJ, Engebrecht, J, Rose, K, Sung, TC, Rudge, SA

J Biol Chem 1995
9140189 A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily

Cao, JX, Upton, C, Koop, BF

Virus Res 1997
9761774 Characterization of human PLD2 and the analysis of PLD isoform splice variants

Steed, PM, Lasala, DJ, Boyar, WC, Clark, KL

FASEB J 1998
Catalyst Activity

phospholipase D activity of PLD1-4/6 [endoplasmic reticulum membrane]

Inferred From
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