PI is hydrolyzed to 2-acyl LPI by PLA2[13]

Stable Identifier
R-HSA-1482932
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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PI is hydrolyzed to 2-acyl LPI by PLA2[13]
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At the endoplasmic reticulum (ER) membrane, phosphatidylinositol (PI) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 delta/epsilon (PLA2G4D/E) Ghomashchi et al. 2010). This produces 2-acyl lysophosphatidylinositol (LPI). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolyzing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.

Literature References
PubMed ID Title Journal Year
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Lehr, M, Gelb, MH, Aloulou, A, Naika, GS, Bollinger, JG, Ghomashchi, F, Leslie, CC

J Biol Chem 2010
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Catalyst Activity

phospholipase A1 activity of PLA2(13) [cytosol]

Physical Entity
PLA2(13) [cytosol] (Homo sapiens)
Activity
phospholipase A1 activity (GO:0008970)
Orthologous Events
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Bos taurus)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Canis familiaris)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Danio rerio)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Dictyostelium discoideum)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Gallus gallus)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Mus musculus)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Rattus norvegicus)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Saccharomyces cerevisiae)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Schizosaccharomyces pombe)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Sus scrofa)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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