PS is hydrolyzed to 2-acyl LPS by PLA2[10]

Stable Identifier
R-HSA-1482897
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the endoplasmic reticulum (ER) membrane, phosphatidylserine (PS) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/delta/zeta (PLA2G4A/D/F) (Ghomashchi et al. 2010). This produces 2-acyl lysophosphatidylserine (LPS). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolyzing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.

Literature References
PubMed ID Title Journal Year
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH

J Biol Chem 2010
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Catalyst Activity
Title
phospholipase A2 activity of PLA2(10) [cytosol]
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Orthologous Events
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Created