CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)

Stable Identifier
R-HSA-1482894
Type
Reaction
Species
Homo sapiens
Compartment
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At the inner mitochondrial membrane (IM), tafazzin (TAZ) converts cardiolipin (CL) and 1-acyl lysophosphatidylethanolamine (LPE) to monolysocardiolipin (MLCL) and phosphatidylethanolamine (PE) (Xu et al. 2003, Xu et al. 2006, Malhotra et al. 2009).

Literature References
PubMed ID Title Journal Year
19416660 Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species

Ren, M, Schlame, M, Xu, Y, Malhotra, A

Biochim Biophys Acta 2009
14551214 Remodeling of cardiolipin by phospholipid transacylation

Schlame, M, Xu, Y, Blanck, TJ, Kelley, RI

J Biol Chem 2003
17082194 The enzymatic function of tafazzin

Ren, M, Schlame, M, Xu, Y, Malhotra, A

J Biol Chem 2006
Participants
Participates
Catalyst Activity

1-acylglycerol-3-phosphate O-acyltransferase activity of TAZ [mitochondrial inner membrane]

Orthologous Events
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