CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)

Stable Identifier
R-HSA-1482894
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the inner mitochondrial membrane (IM), tafazzin (TAZ) converts cardiolipin (CL) and 1-acyl lysophosphatidylethanolamine (LPE) to monolysocardiolipin (MLCL) and phosphatidylethanolamine (PE) (Xu et al. 2003, Xu et al. 2006, Malhotra et al. 2009).

Literature References
PubMed ID Title Journal Year
14551214 Remodeling of cardiolipin by phospholipid transacylation

Xu, Y, Kelley, RI, Blanck, TJ, Schlame, M

J Biol Chem 2003
19416660 Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species

Malhotra, A, Xu, Y, Ren, M, Schlame, M

Biochim Biophys Acta 2009
17082194 The enzymatic function of tafazzin

Xu, Y, Malhotra, A, Ren, M, Schlame, M

J Biol Chem 2006
Participants
Input
Output
Participant Of
hasEvent
Event Information
Reverse Reaction
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Homo sapiens)
Catalyst Activity
Catalyst Activity
Title
1-acylglycerol-3-phosphate O-acyltransferase activity of TAZ [mitochondrial inner membrane]
Physical Entity
TAZ [mitochondrial inner membrane]
Activity
1-acylglycerol-3-phosphate O-acyltransferase activity (0003841)
Orthologous Events
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Bos taurus)
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Caenorhabditis elegans)
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Canis familiaris)
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Danio rerio)
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Dictyostelium discoideum)
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Drosophila melanogaster)
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Gallus gallus)
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Mus musculus)
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Rattus norvegicus)
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Sus scrofa)
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
Cite Us!