Reactome | CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)

CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)

Stable Identifier

R-HSA-1482894

Type

Reaction

Species

Homo sapiens

Compartment

mitochondrial inner membrane

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CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)

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At the inner mitochondrial membrane (IM), tafazzin (TAZ) converts cardiolipin (CL) and 1-acyl lysophosphatidylethanolamine (LPE) to monolysocardiolipin (MLCL) and phosphatidylethanolamine (PE) (Xu et al. 2003, Xu et al. 2006, Malhotra et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19416660	Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species Ren, M, Schlame, M, Xu, Y, Malhotra, A	Biochim Biophys Acta	2009
14551214	Remodeling of cardiolipin by phospholipid transacylation Schlame, M, Xu, Y, Blanck, TJ, Kelley, RI	J Biol Chem	2003
17082194	The enzymatic function of tafazzin Ren, M, Schlame, M, Xu, Y, Malhotra, A	J Biol Chem	2006