DLCL is acylated to MLCL by LCLAT1 (ER)

Stable Identifier
R-HSA-1482867
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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DLCL is acylated to MLCL by LCLAT1 (ER)
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At the endoplasmic reticulum (ER) membrane, lysocardiolipin acyltransferase 1 (LCLAT1) aka ALCAT1 acylates dilysocardiolipin (DLCL) to produce monolysocardiolipin (MLCL) (Zhao et al. 2009).
Literature References
PubMed ID Title Journal Year
19075029 The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids

Zhao, Y, Chen, YQ, Li, S, Konrad, RJ, Cao, G

J Lipid Res 2009
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Catalyst Activity

O-acyltransferase activity of LCLAT1 [endoplasmic reticulum membrane]

Physical Entity
LCLAT1 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
O-acyltransferase activity (GO:0008374)
Orthologous Events
DLCL is acylated to MLCL by LCLAT1 (ER) (Bos taurus)
DLCL is acylated to MLCL by LCLAT1 (ER) (Caenorhabditis elegans)
DLCL is acylated to MLCL by LCLAT1 (ER) (Canis familiaris)
DLCL is acylated to MLCL by LCLAT1 (ER) (Danio rerio)
DLCL is acylated to MLCL by LCLAT1 (ER) (Dictyostelium discoideum)
DLCL is acylated to MLCL by LCLAT1 (ER) (Gallus gallus)
DLCL is acylated to MLCL by LCLAT1 (ER) (Mus musculus)
DLCL is acylated to MLCL by LCLAT1 (ER) (Rattus norvegicus)
DLCL is acylated to MLCL by LCLAT1 (ER) (Saccharomyces cerevisiae)
DLCL is acylated to MLCL by LCLAT1 (ER) (Schizosaccharomyces pombe)
DLCL is acylated to MLCL by LCLAT1 (ER) (Sus scrofa)
DLCL is acylated to MLCL by LCLAT1 (ER) (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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