MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)

Stable Identifier
R-HSA-1482850
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
ReviewStatus
5/5
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MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)
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At the inner mitochondrial membrane (IM), tafazzin (TAZ) converts monolysocardiolipin (MLCL) and phosphatidylethanolamine (PE) to cardiolipin (CL) and 1-acyl lysophosphatidylethanolamine (LPE) (Xu et al. 2003, Xu et al. 2006, Malhotra et al. 2009). Although this reaction is reversible, the net effect of the phospholipase A and acyltransferase reactions drives it towards the formation of LPE and CL.
Literature References
PubMed ID Title Journal Year
19416660 Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species

Malhotra, A, Xu, Y, Ren, M, Schlame, M

Biochim Biophys Acta 2009
14551214 Remodeling of cardiolipin by phospholipid transacylation

Xu, Y, Kelley, RI, Blanck, TJ, Schlame, M

J Biol Chem 2003
17082194 The enzymatic function of tafazzin

Xu, Y, Malhotra, A, Ren, M, Schlame, M

J Biol Chem 2006
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Event Information
Reverse Reaction
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Homo sapiens)
Catalyst Activity

O-acyltransferase activity of TAZ [mitochondrial inner membrane]

Physical Entity
TAZ [mitochondrial inner membrane] (Homo sapiens)
Activity
O-acyltransferase activity (GO:0008374)
Orthologous Events
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Bos taurus)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Caenorhabditis elegans)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Canis familiaris)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Danio rerio)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Dictyostelium discoideum)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Drosophila melanogaster)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Mus musculus)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Rattus norvegicus)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Sus scrofa)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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