MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)

Stable Identifier
R-HSA-1482850
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the inner mitochondrial membrane (IM), tafazzin (TAZ) converts monolysocardiolipin (MLCL) and phosphatidylethanolamine (PE) to cardiolipin (CL) and 1-acyl lysophosphatidylethanolamine (LPE) (Xu et al. 2003, Xu et al. 2006, Malhotra et al. 2009). Although this reaction is reversible, the net effect of the phospholipase A and acyltransferase reactions drives it towards the formation of LPE and CL.

Literature References
PubMed ID Title Journal Year
14551214 Remodeling of cardiolipin by phospholipid transacylation

Xu, Y, Kelley, RI, Blanck, TJ, Schlame, M

J Biol Chem 2003
19416660 Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species

Malhotra, A, Xu, Y, Ren, M, Schlame, M

Biochim Biophys Acta 2009
17082194 The enzymatic function of tafazzin

Xu, Y, Malhotra, A, Ren, M, Schlame, M

J Biol Chem 2006
Participants
Input
Output
Participant Of
hasEvent
Event Information
Reverse Reaction
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Homo sapiens)
Catalyst Activity
Catalyst Activity
Title
O-acyltransferase activity of TAZ [mitochondrial inner membrane]
Physical Entity
TAZ [mitochondrial inner membrane]
Activity
O-acyltransferase activity (0008374)
Orthologous Events
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Bos taurus)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Caenorhabditis elegans)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Canis familiaris)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Danio rerio)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Dictyostelium discoideum)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Drosophila melanogaster)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Gallus gallus)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Mus musculus)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Rattus norvegicus)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Sus scrofa)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)