MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)

Stable Identifier
Reaction [transition]
Homo sapiens
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At the inner mitochondrial membrane (IM), tafazzin (TAZ) converts monolysocardiolipin (MLCL) and phosphatidylethanolamine (PE) to cardiolipin (CL) and 1-acyl lysophosphatidylethanolamine (LPE) (Xu et al. 2003, Xu et al. 2006, Malhotra et al. 2009). Although this reaction is reversible, the net effect of the phospholipase A and acyltransferase reactions drives it towards the formation of LPE and CL.

Literature References
PubMed ID Title Journal Year
14551214 Remodeling of cardiolipin by phospholipid transacylation

Xu, Y, Kelley, RI, Blanck, TJ, Schlame, M

J Biol Chem 2003
19416660 Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species

Malhotra, A, Xu, Y, Ren, M, Schlame, M

Biochim Biophys Acta 2009
17082194 The enzymatic function of tafazzin

Xu, Y, Malhotra, A, Ren, M, Schlame, M

J Biol Chem 2006
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
O-acyltransferase activity of TAZ [mitochondrial inner membrane]
Physical Entity
Orthologous Events
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