Reactome | MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)

MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)

Stable Identifier

R-HSA-1482781

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

ReviewStatus

5/5

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MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)

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At the inner mitochondrial membrane (IM), tafazzin (TAZ) converts monolysocardiolipin (MLCL) and phosphatidylcholine (PC) to cardiolipin (CL) and 1-acyl lysophosphatidylcholine (LPC) (Xu et al. 2003, Xu et al. 2006, Malhotra et al. 2009). Although this reaction is reversible, the net effect of the phospholipase A and acyltransferase reactions drives it towards the formation of LPC and CL.

Literature References

PubMed ID	Title	Journal	Year
19416660	Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species Ren, M, Schlame, M, Xu, Y, Malhotra, A	Biochim Biophys Acta	2009
14551214	Remodeling of cardiolipin by phospholipid transacylation Schlame, M, Xu, Y, Blanck, TJ, Kelley, RI	J Biol Chem	2003
17082194	The enzymatic function of tafazzin Ren, M, Schlame, M, Xu, Y, Malhotra, A	J Biol Chem	2006