MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)

Stable Identifier
R-HSA-1482781
Type
Reaction
Species
Homo sapiens
Compartment
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At the inner mitochondrial membrane (IM), tafazzin (TAZ) converts monolysocardiolipin (MLCL) and phosphatidylcholine (PC) to cardiolipin (CL) and 1-acyl lysophosphatidylcholine (LPC) (Xu et al. 2003, Xu et al. 2006, Malhotra et al. 2009). Although this reaction is reversible, the net effect of the phospholipase A and acyltransferase reactions drives it towards the formation of LPC and CL.

Literature References
PubMed ID Title Journal Year
19416660 Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species

Ren, M, Schlame, M, Xu, Y, Malhotra, A

Biochim Biophys Acta 2009
14551214 Remodeling of cardiolipin by phospholipid transacylation

Schlame, M, Xu, Y, Blanck, TJ, Kelley, RI

J Biol Chem 2003
17082194 The enzymatic function of tafazzin

Ren, M, Schlame, M, Xu, Y, Malhotra, A

J Biol Chem 2006
Participants
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Event Information
Catalyst Activity

O-acyltransferase activity of TAZ [mitochondrial inner membrane]

Orthologous Events
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