At the inner mitochondrial membrane (IM), tafazzin (TAZ) converts monolysocardiolipin (MLCL) and phosphatidylcholine (PC) to cardiolipin (CL) and 1-acyl lysophosphatidylcholine (LPC) (Xu et al. 2003, Xu et al. 2006, Malhotra et al. 2009). Although this reaction is reversible, the net effect of the phospholipase A and acyltransferase reactions drives it towards the formation of LPC and CL.
Ren, M, Schlame, M, Xu, Y, Malhotra, A
Schlame, M, Xu, Y, Blanck, TJ, Kelley, RI
O-acyltransferase activity of TAZ [mitochondrial inner membrane]
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