Reactome | MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)

MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)

Stable Identifier

R-HSA-1482781

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

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MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)

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At the inner mitochondrial membrane (IM), tafazzin (TAZ) converts monolysocardiolipin (MLCL) and phosphatidylcholine (PC) to cardiolipin (CL) and 1-acyl lysophosphatidylcholine (LPC) (Xu et al. 2003, Xu et al. 2006, Malhotra et al. 2009). Although this reaction is reversible, the net effect of the phospholipase A and acyltransferase reactions drives it towards the formation of LPC and CL.

Literature References

PubMed ID	Title	Journal	Year
14551214	Remodeling of cardiolipin by phospholipid transacylation Xu, Y, Kelley, RI, Blanck, TJ, Schlame, M	J Biol Chem	2003
19416660	Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species Malhotra, A, Xu, Y, Ren, M, Schlame, M	Biochim Biophys Acta	2009
17082194	The enzymatic function of tafazzin Xu, Y, Malhotra, A, Ren, M, Schlame, M	J Biol Chem	2006