MLCL is hydrolyzed to DLCL by PLA2G4A (IM)

Stable Identifier
R-HSA-1482759
Type
Reaction
Species
Homo sapiens
Compartment
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At the inner mitochondrial membrane (IM), the phospholipase A2 group IV alpha (PLA2G4A) protein hydrolyzes monolysocardiolipin (MLCL) and produces dilysocardiolipin (DLCL) (Buckland et al. 1998, Sharp et al. 1994).

Literature References
PubMed ID Title Journal Year
9487141 Cardiolipin hydrolysis by human phospholipases A2. The multiple enzymatic activities of human cytosolic phospholipase A2

Kinkaid, AR, Buckland, AG, Wilton, DC

Biochim Biophys Acta 1998
8083230 Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2

Pickard, RT, Sharp, JD, Brems, DN, Miller, JR, Manetta, JV, Strifler, BA, Roberts, EF, Kovacevic, S, Varshavsky, AD, Chiou, XG

J Biol Chem 1994
Participants
Participates
Catalyst Activity

phospholipase A2 activity of PLA2G4A:Ca2+ [mitochondrial inner membrane]

Orthologous Events
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