Reactome | MLCL is hydrolyzed to DLCL by PLA2G4A (IM)

MLCL is hydrolyzed to DLCL by PLA2G4A (IM)

Stable Identifier

R-HSA-1482759

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial matrix

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

MLCL is hydrolyzed to DLCL by PLA2G4A (IM)

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the inner mitochondrial membrane (IM), the phospholipase A2 group IV alpha (PLA2G4A) protein hydrolyzes monolysocardiolipin (MLCL) and produces dilysocardiolipin (DLCL) (Buckland et al. 1998, Sharp et al. 1994).

Literature References

PubMed ID	Title	Journal	Year
9487141	Cardiolipin hydrolysis by human phospholipases A2. The multiple enzymatic activities of human cytosolic phospholipase A2 Kinkaid, AR, Buckland, AG, Wilton, DC	Biochim Biophys Acta	1998
8083230	Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2 Pickard, RT, Sharp, JD, Brems, DN, Miller, JR, Manetta, JV, Strifler, BA, Roberts, EF, Kovacevic, S, Varshavsky, AD, Chiou, XG	J Biol Chem	1994