Reactome | G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)

G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)

Stable Identifier

R-HSA-1482695

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial outer membrane, cytosol

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G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)

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Glycerol-3-phosphate (G3P) is acylated to 1-acyl lysophosphatidic acid (LPA) by the enzymes glycerol-3-phosphate acyltransferase 1 (GPAT, also known as GPAM) and glycerol-3-phosphate acyltransferase 2 (GPAT2), at the outer mitochondrial (OM) membrane (Shindou & Shimizu 2009, Chen et al. 2008, Takeuchi & Reue 2009).

Literature References

PubMed ID	Title	Journal	Year
19336658	Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis Takeuchi, K, Reue, K	Am J Physiol Endocrinol Metab	2009
18238778	AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase Chen, YQ, Kuo, MS, Li, S, Bui, HH, Peake, DA, Sanders, PE, Thibodeaux, SJ, Chu, S, Qian, YW, Zhao, Y, Bredt, DS, Moller, DE, Konrad, RJ, Beigneux, AP, Young, SG, Cao, G	J Biol Chem	2008
18718904	Acyl-CoA:lysophospholipid acyltransferases Shindou, H, Shimizu, T	J Biol Chem	2009