G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)

Stable Identifier
R-HSA-1482695
Type
Reaction
Species
Homo sapiens
Compartment
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Glycerol-3-phosphate (G3P) is acylated to 1-acyl lysophosphatidic acid (LPA) by the enzymes glycerol-3-phosphate acyltransferase 1 (GPAT, also known as GPAM) and glycerol-3-phosphate acyltransferase 2 (GPAT2), at the outer mitochondrial (OM) membrane (Shindou & Shimizu 2009, Chen et al. 2008, Takeuchi & Reue 2009).

Literature References
PubMed ID Title Journal Year
18238778 AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase

Kuo, MS, Qian, YW, Li, S, Bredt, DS, Chu, S, Beigneux, AP, Bui, HH, Sanders, PE, Thibodeaux, SJ, Zhao, Y, Cao, G, Chen, YQ, Moller, DE, Peake, DA, Young, SG, Konrad, RJ

J Biol Chem 2008
19336658 Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis

Reue, K, Takeuchi, K

Am J Physiol Endocrinol Metab 2009
18718904 Acyl-CoA:lysophospholipid acyltransferases

Shindou, H, Shimizu, T

J Biol Chem 2009
Participants
Participates
Catalyst Activity

glycerol-3-phosphate O-acyltransferase activity of GPAM/GPAT2 [mitochondrial outer membrane]

Orthologous Events
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