G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)

Stable Identifier
R-HSA-1482695
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Glycerol-3-phosphate (G3P) is acylated to 1-acyl lysophosphatidic acid (LPA) by the enzymes glycerol-3-phosphate acyltransferase 1 (GPAT, also known as GPAM) and glycerol-3-phosphate acyltransferase 2 (GPAT2), at the outer mitochondrial (OM) membrane (Shindou & Shimizu 2009, Chen et al. 2008, Takeuchi & Reue 2009).

Literature References
PubMed ID Title Journal Year
19336658 Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis

Takeuchi, K, Reue, K

Am J Physiol Endocrinol Metab 2009
18238778 AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase

Chen, YQ, Kuo, MS, Li, S, Bui, HH, Peake, DA, Sanders, PE, Thibodeaux, SJ, Chu, S, Qian, YW, Zhao, Y, Bredt, DS, Moller, DE, Konrad, RJ, Beigneux, AP, Young, SG, Cao, G

J Biol Chem 2008
18718904 Acyl-CoA:lysophospholipid acyltransferases

Shindou, H, Shimizu, T

J Biol Chem 2009
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
glycerol-3-phosphate O-acyltransferase activity of GPAM/GPAT2 [mitochondrial outer membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created