Reactome | G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)

G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)

Stable Identifier

R-HSA-1482695

Type

Reaction

Species

Homo sapiens

Compartment

mitochondrial outer membrane, cytosol

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G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)

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Glycerol-3-phosphate (G3P) is acylated to 1-acyl lysophosphatidic acid (LPA) by the enzymes glycerol-3-phosphate acyltransferase 1 (GPAT, also known as GPAM) and glycerol-3-phosphate acyltransferase 2 (GPAT2), at the outer mitochondrial (OM) membrane (Shindou & Shimizu 2009, Chen et al. 2008, Takeuchi & Reue 2009).

Literature References

PubMed ID	Title	Journal	Year
18238778	AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase Kuo, MS, Qian, YW, Li, S, Bredt, DS, Chu, S, Beigneux, AP, Bui, HH, Sanders, PE, Thibodeaux, SJ, Zhao, Y, Cao, G, Chen, YQ, Moller, DE, Peake, DA, Young, SG, Konrad, RJ	J Biol Chem	2008
19336658	Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis Reue, K, Takeuchi, K	Am J Physiol Endocrinol Metab	2009
18718904	Acyl-CoA:lysophospholipid acyltransferases Shindou, H, Shimizu, T	J Biol Chem	2009