At the endoplasmic reticulum (ER) membrane, 1-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009, Sharp et al. 1994) or by Phospholipase B1-like (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.
Lehr, M, Gelb, MH, Aloulou, A, Naika, GS, Bollinger, JG, Ghomashchi, F, Leslie, CC
Waku, K, Nakanishi, H, Yamashita, A, Kawagishi, N, Kamata, R, Sugiura, T, Suzuki, H
Venge, P, Zhao, L, Larsson, A, Xu, S
Waku, K, Tanaka, K, Kumazawa, T, Yamashita, A, Kamata, R, Sugiura, T, Koga, H, Suzuki, N
Pickard, RT, Sharp, JD, Brems, DN, Miller, JR, Manetta, JV, Strifler, BA, Roberts, EF, Kovacevic, S, Varshavsky, AD, Chiou, XG
lysophospholipase activity of PLA2(8) [cytosol]
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