At the endoplasmic reticulum (ER) membrane, 1-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009, Sharp et al. 1994) or by Phospholipase B1-like (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.
Yamashita, A, Kamata, R, Kawagishi, N, Nakanishi, H, Suzuki, H, Sugiura, T, Waku, K
Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH
Xu, S, Zhao, L, Larsson, A, Venge, P
Yamashita, A, Tanaka, K, Kamata, R, Kumazawa, T, Suzuki, N, Koga, H, Waku, K, Sugiura, T
Sharp, JD, Pickard, RT, Chiou, XG, Manetta, JV, Kovacevic, S, Miller, JR, Varshavsky, AD, Roberts, EF, Strifler, BA, Brems, DN
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