PA is hydrolysed to 1-acyl LPA by PLA2G2A

Stable Identifier
R-HSA-1482679
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Locations in the PathwayBrowser
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Summation

At the endoplasmic reticulum (ER) membrane, phosphatidic acid (PA) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 2A (PLA2G2A), to form 1-acyl lysophosphatidic acid (LPA) (Singer et al. 2002).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phospholipase A2 activity of PLA2G2A:Ca2+ [endoplasmic reticulum membrane]
Physical Entity
PLA2G2A:Ca2+ [endoplasmic reticulum membrane]
Activity
phospholipase A2 activity (0004623)
Orthologous Events
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Bos taurus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Caenorhabditis elegans)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Gallus gallus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Mus musculus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Rattus norvegicus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Sus scrofa)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Taeniopygia guttata)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Xenopus tropicalis)