PA is hydrolysed to 1-acyl LPA by PLA2G2A

Stable Identifier
R-HSA-1482679
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Locations in the PathwayBrowser
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Summation

At the endoplasmic reticulum (ER) membrane, phosphatidic acid (PA) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 2A (PLA2G2A), to form 1-acyl lysophosphatidic acid (LPA) (Singer et al. 2002).

Literature References
PubMed ID Title Journal Year
12359733 Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2

Singer, AG, Ghomashchi, F, Le Calvez, C, Bollinger, J, Bezzine, S, Rouault, M, Sadilek, M, Nguyen, E, Lazdunski, M, Lambeau, G, Gelb, MH

J Biol Chem 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phospholipase A2 activity of PLA2G2A:Ca2+ [endoplasmic reticulum membrane]
Physical Entity
PLA2G2A:Ca2+ [endoplasmic reticulum membrane]
Activity
phospholipase A2 activity (0004623)
Orthologous Events
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Bos taurus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Caenorhabditis elegans)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Gallus gallus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Mus musculus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Rattus norvegicus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Sus scrofa)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Taeniopygia guttata)
Authored
Williams, MG  (2011-09-14)