PA is hydrolysed to 1-acyl LPA by PLA2G2A

Stable Identifier
R-HSA-1482679
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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PA is hydrolysed to 1-acyl LPA by PLA2G2A
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At the endoplasmic reticulum (ER) membrane, phosphatidic acid (PA) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 2A (PLA2G2A), to form 1-acyl lysophosphatidic acid (LPA) (Singer et al. 2002).
Literature References
PubMed ID Title Journal Year
12359733 Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2

Gelb, MH, Le Calvez, C, Ghomashchi, F, Rouault, M, Singer, AG, Sadilek, M, Bollinger, J, Bezzine, S, Lambeau, G, Lazdunski, M, Nguyen, E

J Biol Chem 2002
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Catalyst Activity

phospholipase A2 activity of PLA2G2A:Ca2+ [endoplasmic reticulum membrane]

Physical Entity
PLA2G2A:Ca2+ [endoplasmic reticulum membrane] (Homo sapiens)
Activity
phospholipase A2 activity (GO:0004623)
Orthologous Events
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Bos taurus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Caenorhabditis elegans)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Drosophila melanogaster)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Gallus gallus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Mus musculus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Rattus norvegicus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Sus scrofa)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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