PA is hydrolysed to 1-acyl LPA by PLA2[1]

Stable Identifier
R-HSA-1482656
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the endoplasmic reticulum (ER) membrane, phosphatidic acid (PA) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) to form 1-acyl lysophosphatidic acid (LPA) (Ghomashchi et al. 2010).

Literature References
PubMed ID Title Journal Year
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH

J Biol Chem 2010
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phospholipase A2 activity of PLA2(1) [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created