Reactome | 2-acyl LPE is acylated to PE by LPEAT

2-acyl LPE is acylated to PE by LPEAT

Stable Identifier

R-HSA-1482646

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

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At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 2-acyl lysophosphatidylethanolamine (LPE) to form phosphatidylethanolamine (PE). The lysophospholipid acyltransferases involved are: lysophospholipid acyltransferase 1 (MBOAT1) aka LPEAT1 (Gijon et al. 2008, Hishikawa et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008, Ye et al. 2005); lysophospholipid acyltransferase 2 (MBOAT2) aka LPCAT4 (Hishikawa et al. 2008, Gijon et al. 2008); lysophospholipid acyltransferase 5 (LPCAT3) (Hishikawa et al. 2008, Zhao et al. 2008, Gijon et al. 2008, Jain et al. 2009, Kazachkov et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18781350	Substrate preferences of a lysophosphatidylcholine acyltransferase highlight its role in phospholipid remodeling Kazachkov, M, Chen, Q, Wang, L, Zou, J	Lipids	2008
18772128	Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils Gijon, MA, Riekhof, WR, Zarini, S, Murphy, RC, Voelker, DR	J Biol Chem	2008
18195019	Identification and characterization of a major liver lysophosphatidylcholine acyltransferase Zhao, Y, Chen, YQ, Bonacci, TM, Bredt, DS, Li, S, Bensch, WR, Moller, DE, Kowala, M, Konrad, RJ, Cao, G	J Biol Chem	2008
18458083	Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 Cao, J, Shan, D, Revett, T, Li, D, Wu, L, Liu, W, Tobin, JF, Gimeno, RE	J Biol Chem	2008
18287005	Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity Hishikawa, D, Shindou, H, Kobayashi, S, Nakanishi, H, Taguchi, R, Shimizu, T	Proc Natl Acad Sci U S A	2008
19351971	Characterization of human lysophospholipid acyltransferase 3 Jain, S, Zhang, X, Khandelwal, PJ, Saunders, AJ, Cummings, BS, Oelkers, P	J Lipid Res	2009