2-acyl LPE is acylated to PE by LPEAT

Stable Identifier
R-HSA-1482646
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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2-acyl LPE is acylated to PE by LPEAT
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At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 2-acyl lysophosphatidylethanolamine (LPE) to form phosphatidylethanolamine (PE). The lysophospholipid acyltransferases involved are: lysophospholipid acyltransferase 1 (MBOAT1) aka LPEAT1 (Gijon et al. 2008, Hishikawa et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008, Ye et al. 2005); lysophospholipid acyltransferase 2 (MBOAT2) aka LPCAT4 (Hishikawa et al. 2008, Gijon et al. 2008); lysophospholipid acyltransferase 5 (LPCAT3) (Hishikawa et al. 2008, Zhao et al. 2008, Gijon et al. 2008, Jain et al. 2009, Kazachkov et al. 2008).
Literature References
PubMed ID Title Journal Year
18772128 Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils

Gijon, MA, Riekhof, WR, Zarini, S, Murphy, RC, Voelker, DR

J Biol Chem 2008
18781350 Substrate preferences of a lysophosphatidylcholine acyltransferase highlight its role in phospholipid remodeling

Kazachkov, M, Chen, Q, Wang, L, Zou, J

Lipids 2008
18195019 Identification and characterization of a major liver lysophosphatidylcholine acyltransferase

Zhao, Y, Chen, YQ, Bonacci, TM, Bredt, DS, Li, S, Bensch, WR, Moller, DE, Kowala, M, Konrad, RJ, Cao, G

J Biol Chem 2008
18458083 Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2

Cao, J, Shan, D, Revett, T, Li, D, Wu, L, Liu, W, Tobin, JF, Gimeno, RE

J Biol Chem 2008
18287005 Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity

Hishikawa, D, Shindou, H, Kobayashi, S, Nakanishi, H, Taguchi, R, Shimizu, T

Proc Natl Acad Sci U S A 2008
19351971 Characterization of human lysophospholipid acyltransferase 3

Jain, S, Zhang, X, Khandelwal, PJ, Saunders, AJ, Cummings, BS, Oelkers, P

J Lipid Res 2009
Participants
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Output
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Catalyst Activity

2-acylglycerol-3-phosphate O-acyltransferase activity of LPEAT [endoplasmic reticulum membrane]

Physical Entity
LPEAT [endoplasmic reticulum membrane] (Homo sapiens)
Activity
2-acylglycerol-3-phosphate O-acyltransferase activity (GO:0047144)
Orthologous Events
2-acyl LPE is acylated to PE by LPEAT (Bos taurus)
2-acyl LPE is acylated to PE by LPEAT (Caenorhabditis elegans)
2-acyl LPE is acylated to PE by LPEAT (Canis familiaris)
2-acyl LPE is acylated to PE by LPEAT (Dictyostelium discoideum)
2-acyl LPE is acylated to PE by LPEAT (Drosophila melanogaster)
2-acyl LPE is acylated to PE by LPEAT (Gallus gallus)
2-acyl LPE is acylated to PE by LPEAT (Mus musculus)
2-acyl LPE is acylated to PE by LPEAT (Plasmodium falciparum)
2-acyl LPE is acylated to PE by LPEAT (Rattus norvegicus)
2-acyl LPE is acylated to PE by LPEAT (Saccharomyces cerevisiae)
2-acyl LPE is acylated to PE by LPEAT (Schizosaccharomyces pombe)
2-acyl LPE is acylated to PE by LPEAT (Sus scrofa)
2-acyl LPE is acylated to PE by LPEAT (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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