2-acyl LPE is hydrolyzed to GPETA by PLA2G4C

Stable Identifier
R-HSA-1482545
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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2-acyl LPE is hydrolyzed to GPETA by PLA2G4C
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At the endoplasmic reticulum (ER) membrane, membrane-bound cytosolic phospholipase A2 gamma (PLA2G4C) hydrolyzes 2-acyl lysophosphatidylethanolamine (LPE) to produce glycerophosphoethanolamine (GPETA) (Yamashita et al. 2005, Yamashita et al. 2009).
Literature References
PubMed ID Title Journal Year
15944408 Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)

Yamashita, A, Kamata, R, Kawagishi, N, Nakanishi, H, Suzuki, H, Sugiura, T, Waku, K

J Biochem 2005
19501189 Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma)

Yamashita, A, Tanaka, K, Kamata, R, Kumazawa, T, Suzuki, N, Koga, H, Waku, K, Sugiura, T

Biochim Biophys Acta 2009
Participants
Input
Output
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as an event of
Catalyst Activity

phosphatidylcholine lysophospholipase activity of PLA2G4C [endoplasmic reticulum membrane]

Physical Entity
PLA2G4C [endoplasmic reticulum membrane] (Homo sapiens)
Activity
phosphatidylcholine lysophospholipase activity (GO:0004622)
Orthologous Events
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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